2. 疾病领域
  3. 癌症 消化系统疾病
  4. 肝癌 消化系统癌症
  5. 2-Nitropropane

2-Nitropropane 是一种可作为工业溶剂和化学中间体的 DNA 损伤诱导剂，具备口服活性。2-Nitropropane 可在大鼠骨髓细胞中诱导氧化性 DNA 损伤，是可诱发肝癌的大鼠致癌物。2-Nitropropane 可用于肝细胞癌等癌症的相关研究。

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2-Nitropropane

2-Nitropropane Chemical Structure

CAS No. : 79-46-9

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2-Nitropropane 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Nitropropane is a DNA damage inducer that serves as an industrial solvent and chemical intermediate, with oral activity. 2-Nitropropane induces oxidative DNA damage in rat bone marrow cells and acts as a rat hepatocarcinogen. 2-Nitropropane is applicable to research related to cancers such as hepatocellular carcinoma[1][2][3].

体外研究
(In Vitro)

2-nitropropane (0.1-1 mM, 20 h) 可在 0.1 mM 浓度下诱导雄性 Wistar 大鼠肝细胞出现显著的非程序性 DNA 合成[3]。
2-nitropropane (0.25-6.25 mM, 4 h) 可在雄性 Wistar 大鼠肝细胞 (含量最高) 和雄性 BALB/c 小鼠肝细胞 (含量较低) 中生成具有电化学活性的修饰脱氧核苷[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2-Nitropropane 相关抗体:
体内研究
(In Vivo)

2-Nitropropane (100 mg/kg；腹腔注射；单次给药) 会对大鼠骨髓细胞造成 DNA 损伤[1]。
2-Nitropropane (1 mmol/kg；灌胃给药；每周 3 次；持续 16 周) 可在 Sprague-Dawley 大鼠中诱发 100%发生率的肝癌[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male, 6 weeks old, 200-220 g body weight)[1]
Dosage: 100 mg/kg
Administration: i.p.; single dose
Result: Measured average comet tail length in bone marrow cells as 9.61 μm; detected 8-oxodG levels in DNA as 5.14 per 10⁵ dG; observed a close correlation between comet tail length and 8-oxodG level.
Animal Model: Sprague-Dawley Rats (male, 150-160 g)[2]
Dosage: 1 mmol/kg
Administration: i.g.; three times per week; 16 weeks
Result: Observed benign liver tumors and malignant liver tumors; Detected lung metastases; Recorded significantly lower body weights throughout the study compared to other groups
分子量

89.09

Formula

C3H7NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2-Nitropropane 相关分类

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Keywords:

2-Nitropropane79-46-9DNA damage inducerhepatocellular carcinomaWistar ratsSprague-Dawley RatsInhibitorinhibitorinhibit

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