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  4. 3-Ethoxybenzamide

3-Ethoxybenzamide  (Synonyms: 3-乙氧基苯甲酰胺)

目录号: HY-W237019
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3-Ethoxybenzamide 是一种具有抗菌活性的烷氧基苯甲酰胺类化合物和 FtsZ 抑制剂，能透过血脑屏障。3-Ethoxybenzamide 在体内分布广泛且迅速，能在多种组织与血液间快速达到平衡并被肝细胞线性摄取。3-Ethoxybenzamide 完全依赖肝脏微粒体氧化作用进行清除，主要代谢产物为水杨酰胺。3-Ethoxybenzamide 可用于研究细菌感染。

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3-Ethoxybenzamide

3-Ethoxybenzamide Chemical Structure

CAS No. : 55836-69-6

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3-Ethoxybenzamide 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3-Ethoxybenzamide is an alkoxybenzamide compound with antibacterial activity and a FtsZ inhibitor that can cross the blood-brain barrier. 3-Ethoxybenzamide distributes widely and rapidly in vivo, rapidly reaches equilibrium between various tissues and blood, and is linearly taken up by hepatocytes. 3-Ethoxybenzamide is completely dependent on hepatic microsomal oxidation for clearance, with salicylamide as its major metabolite. 3-Ethoxybenzamide can be used for the study of bacterial infections[1][2].

体外研究
(In Vitro)

3-Ethoxybenzamide (0.1-1.0 mM; 0.5-10 min) 可快速与大鼠红细胞达到平衡，且在所有测试浓度下，其全血-血浆分配系数均等于 1[1]。
3-Ethoxybenzamide 在大鼠肝微粒体中发生脱乙基化，校正后的动力学参数为 Vmax1 = 0.124 μmol/min/g[1]。
3-Ethoxybenzamide (500-2000 μg/mL) 可抑制 Bacillus subtilis 168 的细菌生长，其 MIC 为 2000 μg/mL，并在 500 μg/mL 浓度下诱导细胞分裂抑制[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3-Ethoxybenzamide 相关抗体:

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[2]

Cell Line: Staphylococcus aureus, Bacillus subtilis 168
Concentration: 500-2000 μg/mL
Incubation Time: /
Result: Against Staphylococcus aureus and Bacillus subtilis 168 with MIC of 1024 μg/mL and 2000 μg/mL, respectively.
体内研究
(In Vivo)

3-Ethoxybenzamide (10-80 mg/kg；静脉注射；单次推注) 在健康雄性白化兔中模拟的血浆和组织浓度，与 10 mg/kg 和 20 mg/kg 静脉推注剂量下的观测值高度吻合，但该模型无法准确预测 80 mg/kg 剂量组的终末消除相[1]。
3-Ethoxybenzamide (20-100 mg/kg；静脉注射；单次推注) 在健康的 250 g 大鼠中模拟得到的血浆和组织浓度，与 20 mg/kg、50 mg/kg 和 100 mg/kg 静脉推注剂量下的实测值吻合度良好，仅在小肠和肌肉组织的浓度曲线中存在微小差异[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: albino (male, 1.7-2.3 kg)[1]
Dosage: 10 mg/kg; 20 mg/kg; 80 mg/kg
Administration: i.v.; single bolus
Result: Showed very good agreement between simulated and observed plasma concentrations at 10 mg/kg and 20 mg/kg doses.
Systemically higher observed plasma concentrations than simulated values in the terminal elimination phase at 80 mg/kg dose.
Showed general agreement between simulated and observed tissue concentrations in brain, kidney, and liver at 20 mg/kg dose, despite some variability in measured tissue levels.
Animal Model: 250 g body weight[1]
Dosage: 20 mg/kg; 50 mg/kg; 100 mg/kg
Administration: i.v.; single bolus
Result: Predicted observed rat plasma data reasonably well with simulated plasma concentration-time profiles at 20 mg/kg, 50 mg/kg, and 100 mg/kg doses.
Showed reasonable agreement between simulated and observed tissue concentrations in most tissues (brain, lung, liver, kidney, muscle, skin, adipose) at 20 mg/kg dose.
Overestimated peak levels in simulated small intestine concentrations and showed a delayed peak not seen in observed data in simulated muscle concentrations at 20 mg/kg dose.
分子量

165.19

Formula

C9H11NO2
CAS 号
中文名称

3-乙氧基苯甲酰胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3-Ethoxybenzamide 相关分类

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Keywords:

3-Ethoxybenzamide55836-69-63-乙氧基苯甲酰胺Bacterialliver microsomesblood-brain barrierBacillus subtilis 168albino rabbitssalicylamideStaphylococcus aureusrat erythrocytesbacterial infectionsFtsZrat hepatocytesInhibitorinhibitorinhibit

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