2. Academic Validation
  3. Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

  • Bioorg Med Chem Lett. 2009 Jan 15;19(2):524-7. doi: 10.1016/j.bmcl.2008.11.021.
Lloyd G Czaplewski 1,  Ian Collins,  E Andrew Boyd,  David Brown,  Stephen P East,  Mihaly Gardiner,  Rowena Fletcher,  David J Haydon,  Vincent Henstock,  Peter Ingram,  Clare Jones,  Caterina Noula,  Leanne Kennison,  Chris Rockley,  Valerie Rose,  Helena B Thomaides-Brears,  Rebecca Ure,  Mark Whittaker,  Neil R Stokes
Affiliations

Affiliation

  • 1 Prolysis Ltd, Begbroke Science Park, Sandy Lane, Yarnton, Oxfordshire OX5 1PF, UK.
PMID: 19064318 DOI: 10.1016/j.bmcl.2008.11.021
Abstract

3-Methoxybenzamide is a weak inhibitor of the essential Bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.

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