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Substrate

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2657

抑制剂 & 激动剂

化合物筛选库

211

荧光染料

409

生化试剂

712

多肽产品

MCE 试剂盒

抗体抑制剂

297

天然产物

重组蛋白

109

同位素标记物

抗体

点击化学

寡核苷酸

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Targets Recommended: MARCKS

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-126389B

*Chitin, from shrimp shells (chitinase substrate)*	TNF Receptor Interleukin Related	Inflammation/Immunology
几丁质,来源于虾壳 (几丁质酶底物) Chitin, from shrimp shells (chitinase substrate) 是几丁质酶的底物，)是节肢动物细胞外基质的结构组成成分。Chitin, from shrimp shells (chitinase substrate) 可激活固有免疫以产生炎性细胞因子，造成器官损伤，并参与过敏性及自身免疫性疾病的发生。Chitin, from shrimp shells (chitinase substrate) 是职业性过敏的常见诱因；外源性几丁质会损害健康，而内源性几丁质则具有保护作用。\n

HY-P3936

Endotoxin Substrate	Fluorescent Dye	Others
鲎试剂三肽 Endotoxin Substrate (Boc-LGR-pNA) 是一种显色底物，可用于内毒素的定量测定。

HY-P1883A

*Bacterial Sortase Substrate* III, Abz/DNP TFA**	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP TFA 是一种内部淬灭的荧光肽底物。金黄色葡萄球菌转肽酶分选酶A (SrtA) 与 Bacterial Sortase Substrate III, Abz/DNP 反应，裂解并催化苏氨酸的羧基与细胞壁交联桥的氨基之间形成酰胺键。可以在 Ex/Em=320 nm/420 nm 下检测该底物的切割。

HY-P3815

*Casein Kinase 2 Substrate* Peptide** 2 篇文献验证	Casein Kinase	Others
Casein Kinase 2 Substrate Peptide 是一种常见的 CK2 底物肽。Casein Kinase 2 Substrate Peptide 的 C 端与 5-[(2-氨基乙基)氨基]萘-1-磺酸 (EDANS) 结合。Casein Kinase 2 Substrate Peptide 可用于蛋白激酶 CK2 活性的测定。

HY-P5990

Prostate Specific Antigen Substrate	PSMA	Cancer
Prostate Specific Antigen Substrate 是前列腺特异性抗原 (PSA) 荧光底物。Prostate Specific Antigen Substrate 可用于检测 PSA 酶活性。

HY-P3949

*Fluorescent Substrate* for Glu-Specific Proteases**	Fluorescent Dye	Others
Fluorescent Substrate for Glu-Specific Proteases 是一种 V8 蛋白酶特异性显色底物。

HY-P2179

*MMP-1/MMP-9 Substrate, Fluorogenic*	Fluorescent Dye MMP	Others
MMP-1/MMP-9 Substrate, Fluorogenic 是 MMP-1 和 MMP-9 的荧光底物。Ex/Em=340/440 nm。

HY-P2503

EGFR Protein Tyrosine Kinase Substrate	EGFR	Cancer
EGFR Protein Tyrosine Kinase Substrate 是EGFR 酪氨酸激酶的底物。

HY-D1208

Alkaline phosphatase substrate	Biochemical Assay Reagents Phosphatase	Others
Alkaline phosphatase substrate 是碱性磷酸酶的化学发光底物。Alkaline phosphatase substrate 可用于酶联免疫分析。

HY-P10602

PKA Regulatory Subunit II Substrate RII phosphopeptide	PKA	Others
PKA Regulatory Subunit II Substrate (RII phosphopeptide) 是一种工具肽，来源于环磷酸腺苷依赖性蛋白激酶 (PKA) 的调节亚基 Type II (RII)。PKA Regulatory Subunit II Substrate 通常用于模拟蛋白激酶的磷酸化作用，并作为蛋白磷酸酶的特异性底物来评估这些酶的活性。

HY-P1785

Abl Cytosolic Substrate Abltide	Bcr-Abl	Cancer
Abl Cytosolic Substrate是Abl 酪氨酸激酶的底物。Abl 蛋白酪氨酸激酶是v-AbI蛋白酪氨酸激酶的一种截断形式，是Abelson小鼠白血病病毒Gag-Abl融合蛋白的一个伙伴。

HY-P2456

MBP MAPK Substrate 1 篇文献验证	p38 MAPK	Others
MBP MAPK Substrate 可以用作 MAPK 的外源底物。

HY-134961

Z-Ala-Arg-Arg-AMC 1 篇文献验证 Fluorogenic Proteasome Substrate; Z-ARR-AMC	Proteasome	Others
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) 是一种荧光底物，用于测定蛋白酶体的胰蛋白酶样活性。

HY-P2498A

*Cathepsin D and E FRET Substrate* acetate**	Cathepsin	Cancer
Cathepsin D and E FRET Substrate acetate 为 cathepins D 和 E 的荧光底物 (fluorogenic substrate)，而不是 B、H 或 I 的荧光底物，它的裂解发生在 Phe-Phe 酰胺键处。Cathepsin D and E FRET Substrate 是用于组织蛋白酶 D 和组织蛋白酶 E 的常规检测和机制研究的有用工具。(激发波长:328 nm; 发射波长:393 nm)

HY-P10174A

*ADAM-17 Substrate* TFA**	Fluorescent Dye MMP	Others
ADAM-17 Substrate TFA 是 ADAM 的荧光底物。

HY-P10280

*ATR kinase substrate* peptide**	ATM/ATR	Cancer
ATR kinase substrate peptide (ASELPASQPQPFSAKKK) 是 ATR 蛋白激酶的肽底物，可用于检测 ATR 激酶的活性。

HY-P5426

Abl protein tyrosine kinase substrate	Bcr-Abl	Others
Abl protein tyrosine kinase substrate 是一种有生物活性的肽。(Abltide 是 Abl 激酶（Abl 蛋白酪氨酸激酶）的肽底物，Abl 激酶是 Abelson 鼠白血病病毒的 gag-Abl 融合蛋白的伴侣。用于蛋白质印迹和激酶测定。)

HY-P5432

IRAK-4 Peptide substrate IRAK-1 (360-380)	IRAK	Others
IRAK-4 Peptide substrate (IRAK-1 (360-380)) 是一种有生物活性的肽。(这是 Interleukin-1 受体相关激酶 (IRAK) 4 的底物肽)

HY-P10042

S6K Substrate	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate 是活性蛋白激酶的底物，包括 CLK2、MRCKalpha、MRCKbeta、p70S6K、ROCK1、ROCK2、RSK1、RSK3、PIM1。

HY-P0320

*EGF Receptor Substrate* 2 (Phospho-Tyr5)**	Phosphatase	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate，一种生物活性肽，是一种酪氨酸磷酸底物。EGF Receptor Substrate 2 (Phospho-Tyr5) acetate 可用于检测蛋白酪氨酸磷酸酶活性。

HY-155002

*hCYP3A4 Fluorogenic substrate* 1**	Cytochrome P450	Metabolic Disease
hCYP3A4 Fluorogenic substrate 1 是一种强效 hCYP3A4 荧光底物，K_m 值为 0.36 μM。hCYP3A4 Fluorogenic substrate 1 可用于细胞和体内成像。

HY-P5965

BiP substrate	HSP	Others
BiP substrate 是 BiP 的肽底物，可用于测量 BiP ATPase 活性。

HY-P2558

*GSK3 Substrate, α, β subunit*	GSK-3	Others
GSK3 Substrate, α, β subunit 是糖原合酶激酶-3 (GSK-3) 的肽底物，可用于测量 GSK-3 活性。

HY-P2664

MeOSuc-AAPM-PNA Cathepsin G Substrate	Biochemical Assay Reagents	Others
Cathepsin G substrate 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。

HY-P3934

*HIV Protease Substrate* I**	HIV Protease	Infection
HIV Protease Substrate I 是 HIV-1 蛋白酶的显色底物。HIV Protease Substrate I 具有 HIV 蛋白酶的裂解位点。

HY-P10043

MMP-1 Substrate	MMP	Others
MMP-1 Substrate 是一种基质金属蛋白酶-1 (MMP-1) 选择性底物，可用于 MMP-1 酶活性的荧光测定。

HY-D2284

SGPL1 fluorogenic substrate Sphingosine-1-phosphate lyase fluorogenic Substrate	Fluorescent Dye	Cancer
SGPL1 fluorogenic substrate 是鞘氨醇-1-磷酸裂解酶 (SGPL1) 的荧光底物，可用于测量鞘氨醇-1-磷酸裂解酶的活性。

HY-P3818

PKCδ Peptide Substrate	PKC	Others
PKCδ Peptide Substrate 是一种 δ-type PKC 的绝对特异性底物，其序列与含有 Thr-431 的小鼠 eEF-1α 序列 422-443 相对应。

HY-P1344A

*DAPK Substrate* Peptide TFA**	DAPK	Cancer
DAPK Substrate Peptide TFA 是一种合成的死亡相关蛋白激酶 (DAPK) 的肽底物， K_m 为 9 μM。

HY-P1561

PKG Substrate	PKG	Neurological Disease
PKG Substrate 是一种 cGMP 依赖性的蛋白激酶 (PKG) 的选择性底物。

HY-170462

CSPD substrate	Biochemical Assay Reagents	Others
CSPD 显色底物 CSPD substrate 是碱性磷酸酶的化学发光底物。CSPD substrate 提供增强的碱性磷酸酶敏感性和更简化的检测。

HY-P2414

MMP-13 Substrate	MMP	Inflammation/Immunology
MMP-13 Substrate 是 MMP-13 的底物。MMP-13 Substrate 可用于骨关节炎 (OA) 的研究。

HY-P2498

Cathepsin D and E FRET Substrate	Cathepsin	Others
Cathepsin D and E FRET Substrate 为 cathepins D 和 E 的荧光底物 (fluorogenic substrate)，而不是 B、H 或 I 的荧光底物，它的裂解发生在 Phe-Phe 酰胺键处。Cathepsin D and E FRET Substrate 是用于组织蛋白酶 D 和组织蛋白酶 E 的常规检测和机制研究的有用工具。(激发波长:328 nm; 发射波长:393 nm)

HY-P3948

*Fluorescent Substrate* for Pro-Specific Proteases**	Fluorescent Dye	Others
Fluorescent Substrate for Pro-Specific Proteases 是 Pro-Specific 蛋白酶的荧光底物。Fluorescent Substrate for Pro-Specific Proteases 可用于检测靶标酶的水解速率和活性。

HY-P3921

Casein Kinase II Substrate	Casein Kinase	Cancer
Casein Kinase II Substrate 是一种酪蛋白激酶 II (CK2) 肽底物，可被 CK2 选择性磷酸化。

HY-P3743

p60c-src Substrate	Src Others	Others
p60c-src Substrate 是一种高效特异性的 p60c-src 蛋白酪氨酸激酶 (PTK) 的底物。p60c-src Substrate 可用于合成嵌合支化多肽。

HY-P3947

*Fluorescent Substrate* for Subtillsin**	Ser/Thr Protease	Infection
Fluorescent Substrate for Subtillsin 可用于检测 Subtillsin 的酶活。Subtilisin 是一种细菌丝氨酸蛋白酶。

HY-P3878

*Renin substrate* 1**	Renin	Cardiovascular Disease
Renin substrate 1 是一种对酶具有高亲和力的肾素 (renin) 底物。

HY-138653

Lipase Substrate	Lipase	Metabolic Disease
脂肪酶底物 Lipase Substrate 可用于检测脂肪酶活性。

HY-P1883

*Bacterial Sortase Substrate* III, Abz/DNP**	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP 是一种内部淬灭的荧光肽底物。金黄色葡萄球菌转肽酶分选酶A (SrtA) 与 Bacterial Sortase Substrate III, Abz/DNP 反应，裂解并催化苏氨酸的羧基与细胞壁交联桥的氨基之间形成酰胺键。可以在 Ex/Em=320 nm/420 nm 下检测该底物的切割。

HY-P3773

*p60c-src substrate* II**	Src	Cancer
p60c-src substrate II 是酪氨酸激酶 pp60c-src 的高效五肽底物。

HY-P10050

Calpain substrate	Proteasome	Others
Calpain substrate 是膜不透性荧光钙蛋白酶底物，可用于钙蛋白酶酶活性测定。

HY-P10042A

*S6K Substrate* acetate**	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate acetate 是活性蛋白激酶的底物，包括 CLK2、MRCKalpha、MRCKbeta、p70S6K、ROCK1、ROCK2、RSK1、RSK3、PIM1。

HY-P1113A

*Phospho-Glycogen Synthase Peptide-2(substrate) TFA*	GSK-3	Others
Phospho-Glycogen Synthase Peptide-2 (substrate) 是糖原合酶激酶-3 (GSK-3) 的肽底物，可用于蛋白丝氨酸激酶的亲和纯化。

HY-114315

NQO1 substrate	Quinone Reductase	Cancer
NQO1 substrate 作为一种高效的 NQO1 底物，可用于 NQO1 过表达的、耐药型非小细胞肺癌 (NSCLC) 的研究。

HY-P10541A

*HSP70/DnaK substrate* peptide TFA**	HSP	Others
HSP70/DnaK substrate peptide TFA 是 HSP70/DnaK 分子伴侣能够结合和作用的短肽段。HSP70/DnaK substrate peptide TFA 可用于研究 HSP70/DnaK 在分子伴侣功能中的作用机制。

HY-P3797

Furin Substrate	Furin	Cancer
Furin Substrate 是一种多肽。Furin Substrate 可用于多种生化研究。

HY-P1906

[pThr3]-CDK5 Substrate	CDK	Neurological Disease
[pThr3]-CDK5 Substrate 是 Thr3 磷酸化的 CDK5 底物。[pThr3]-CDK5 Substrate 来自组蛋白 H1，位于组蛋白 H1 上和 CDK5 作用的位点。CDK5 Substrate 被 CDK5 磷酸化为 [pThr3]-CDK5 Substrate 的 K_m 为 6 μM。