2. Metabolic Enzyme/Protease
  3. Liposome
  4. AA76-lipid

AA76-lipid (Compound aa76) 是一种具有精氨酸末端和组氨酸的化合物。AA76-lipid 可用于制备胰腺靶向的脂质纳米颗粒 AH-LNP。AH-LNP 与蛋白质组装后尺寸增大促进 Capsule-filter 介导的胰腺选择性积累和受体介导的内吞作用，从而增强胰腺靶向能力。AA76-lipid 可高胰腺选择性递送 mRNA。AA76-lipid 可用于胰腺癌的研究。

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AA76-lipid

AA76-lipid Chemical Structure

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AA76-lipid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AA76-lipid (Compound aa76) is a compound with a C-terminal arginine and histidine. AA76-lipid can be used to prepare pancreas-targeted lipid nanoparticles AH-LNP. After assembling with proteins, the increased size of AH-LNP promotes Capsule-filter-mediated selective accumulation in the pancreas and receptor-mediated endocytosis, thereby enhancing pancreas-targeting ability. AA76-lipid enables highly pancreas-selective delivery of mRNA. AA76-lipid can be used in the research of pancreatic cancer[1].

体内研究
(In Vivo)

AH-LNP (由 AA76-lipid 组成的化合物) (80 μg/kg；腹腔注射；单次) 在 C57BL/6 小鼠中可高胰腺选择性递送 mRNA，超过 94.7% 的生物发光信号定位于胰腺[1]。
AH-LNP (由 AA76-lipid 组成的化合物) (80 μg/kg；腹腔注射；单次) 可在大鼠、家兔、犬和猪体内以高胰腺选择性递送 mRNA，其产生的生物发光信号中近 90% 定位于胰腺[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

984.45

Formula

C55H101N9O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AA76-lipid 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AA76-lipidLiposomechimeric antigen receptor T cellC57BL/6 micelipid nanoparticlesclathrin-dependent endocytosismajor histocompatibility complex ICD8+ T cellpancreatic stromal cellsinterleukin-2 mRNANOD/Ltj micepancreatic cellsInhibitorinhibitorinhibit

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目录号：
HY-185260
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