2. 多肽产品
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  4. AAPDNRETF

AAPDNRETF 是 H-2Db 分子提呈的一个显性次要组织相容性抗原，该抗原在 C57BL/6 小鼠中表达，能被 C3H.SW 小鼠的 T 细胞识别，从而引发强烈的免疫应答。AAPDNRETF 可通过转移致敏 T 淋巴细胞，在经辐照的 C57BL/6 受体小鼠中引发移植物抗宿主病。AAPDNRETF 可用于移植物抗宿主病的研究。

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Custom Peptide Synthesis

AAPDNRETF

AAPDNRETF Chemical Structure

CAS No. : 179953-98-1

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AAPDNRETF 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AAPDNRETF is a dominant minor histocompatibility antigen presented by H-2Db， which antigen is expressed in C57BL/6 mice and can be recognized by T cells from C3H.SW mice, thereby inducing a strong immune response. AAPDNRETF can induce graft-versus-host disease in irradiated C57BL/6 recipient mice via transfer of sensitized T lymphocytes. AAPDNRETF is applicable to the research of graft-versus-host disease[1].

体外研究
(In Vitro)

AAPDNRETF (0.01 nM-1 μM) 在极低浓度 (10 pM) 下即可有效致敏表达 H-2Db 的靶细胞 (如 T2Db 细胞)，使其被小鼠效应 T 细胞 (CTL) 杀伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AAPDNRETF 相关抗体:
体内研究
(In Vivo)

AAPDNRETF (50-300 µg/只; s.c.; 间隔 7 天，共注射 2 次) 可在雄性 C3H.SW/SnJ 小鼠中诱导产生针对由 H-2Db 呈递的优势 C57BL/6 次要组织相容性抗原的强效、特异性细胞毒性 T 淋巴细胞应答[1]。
AAPDNRETF (300 µg/只; s.c.; 间隔 7 天，共注射 2 次) 可诱导产生 T 淋巴细胞，此类细胞会在经辐照的雄性 C57BL/6J 受体小鼠中引发严重的非致死性移植物抗宿主病以及胸腺发育不全[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H.SW/SnJ (male, 8-20 wk old)[1]
Dosage: 50 µg; 100 µg; 300 µg
Administration: s.c.; administered twice at 7-day intervals
Result: Generated potent CTL responses that killed both unmanipulated C57BL/6 target cells and C3H.SW target cells coated with synthetic AAPDNRETF peptide.
Induced CTL activity comparable to that induced by priming with C57BL/6 cells.
Animal Model: C3H.SW/SnJ (male, 8-20 wk old, donor); C57BL/6J (male, 8-20 wk old, recipient, irradiated 950 rads)[1]
Dosage: 300 µg (donor priming)
Administration: s.c.; administered twice at 7-day intervals (donor priming)
Result: Caused 6/7 recipient mice to develop cutaneous GVHD (hair loss, erythematous lesions, skin ulcerations) starting around day 25, with lesions worsening up to day 60.
Induced significant thymic hypoplasia, with a 50% reduction in total Thy1.2+ thymocytes, CD4+CD8+ double positive thymocytes, CD4+TCRαβ high single positive thymocytes, and CD8+TCRαβ high single positive thymocytes compared to control recipients by day 60.
Maintained 100% recipient survival through day 60.
分子量

1020.05

Formula

C43H65N13O16
CAS 号
Sequence

Ala-Ala-Pro-Asp-Asn-Arg-Glu-Thr-Phe
Sequence Shortening

AAPDNRETF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AAPDNRETF 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AAPDNRETF179953-98-1C57BL/6J miceH-2D?minor histocompatibility antigenC3H.SW Con A blast cellsgraft-versus-host diseasethymic hypoplasiaT2D^b cellsC57BL/6cytotoxic T lymphocytesC3H.SW/SnJ miceInhibitorinhibitorinhibit

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