2. 疾病领域
  3. 炎症和免疫系统疾病
  4. 免疫调节
  5. 免疫抑制

Immunosuppression  (免疫抑制)

免疫抑制是指有意降低免疫系统活性，以防止器官移植排斥反应、控制自身免疫性疾病或实现免疫耐受。免疫抑制通常通过抑制淋巴细胞增殖和活化的药物（例如环孢菌素、硫唑嘌呤、皮质类固醇、FK506和雷帕霉素）或单克隆抗体、移植受者放射治疗或自然免疫缺陷状态（例如HIV/AIDS，此时CD4+ T细胞被耗竭）来诱导。联合疗法可用于平衡急性排斥反应的疗效和最低毒性，而特异性免疫抑制可导致抗原诱导的耐受。该策略在实体器官和骨髓移植以及治疗各种免疫介导疾病中至关重要。

Immunosuppression refers to the deliberate reduction of immune system activity to prevent organ transplant rejection, manage autoimmune diseases, or achieve immunologic tolerance. It is commonly induced through pharmacological agents such as cyclosporine, azathioprine, corticosteroids, FK506, and rapamycin, which inhibit lymphocyte proliferation and activation, or via monoclonal antibodies, irradiation in transplant recipients, or natural immune deficiency states like HIV/AIDS where CD4+ T cells are depleted. Combination therapies are employed to balance efficacy against acute rejection with minimized toxicity, while specific immunosuppression can lead to antigen-induced tolerance. This strategy is essential in solid organ and bone marrow transplantation, as well as in treating various immune-mediated disorders.

Immunosuppression (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P11699
    AAPDNRETF 179953-98-1
    AAPDNRETF 是 H-2Db 分子提呈的一个显性次要组织相容性抗原，该抗原在 C57BL/6 小鼠中表达，能被 C3H.SW 小鼠的 T 细胞识别，从而引发强烈的免疫应答。AAPDNRETF 可通过转移致敏 T 淋巴细胞，在经辐照的 C57BL/6 受体小鼠中引发移植物抗宿主病。AAPDNRETF 可用于移植物抗宿主病的研究。
    AAPDNRETF
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