2. Anti-infection
  3. Fungal
  4. Ac-CoA-IN-1

Ac-CoA-IN-1 是一种酰基-AMP 磷酸酯类似物，同时也是白色念珠菌 (Candida albicans) 乙酰辅酶 A 合成酶 2 的弱抑制剂，对新型隐球菌 (Cryptococcus neoformans) 乙酰辅酶 A 合成酶 1 无抑制活性。Ac-CoA-IN-1 可用于真菌感染的相关研究。

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Ac-CoA-IN-1

Ac-CoA-IN-1 Chemical Structure

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Ac-CoA-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ac-CoA-IN-1 is an acyl-AMP phosphate analog and weak inhibitor of Candida albicans acetyl-CoA synthetase 2, with no activity against Cryptococcus neoformans acetyl-CoA synthetase 1. Ac-CoA-IN-1 crystallizes with Cryptococcus neoformans ACS1 enzyme to yield structural insight for inhibitor design. Ac-CoA-IN-1 can be used for the research of fungal infections[1].

体外研究
(In Vitro)

Ac-CoA-IN-1 (50 μM; 13.6-83.7 mM IC50 range) 可抑制纯化的白色念珠菌 (Candida albicans)ACS2，其 IC50 为 13.6 mM；而对纯化的新型隐球菌 (Cryptococcus neoformans)ACS1 的活性极低，IC50 为 83.7 mM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ac-CoA-IN-1 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Cmax Tmax AUC0-last MRT Bioavailability
Rat[1] 100 mg/kg p.o. 20.0 ng/mL 0.61 h 15.4 ng·h/mL 1.27 h 12.1 %
分子量

359.36

Formula

C11H17N7O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ac-CoA-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-CoA-IN-1Fungalfungal infectionsCryptococcus neoformansTHR 441propyl AMP binding siteCandida albicans acetyl-CoA synthetase 2TRP 334TYR 438Candida albicansASP 527Cryptococcus neoformans acetyl-CoA synthetase 1Inhibitorinhibitorinhibit

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产品名称：
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目录号：
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