AG73 

AG73 is a polypeptide. AG73 is derived from the G domain of the Laminin α1 chain. AG73 binds heparin, Syndecan-1 and Syndecan-4. AG73 promotes the adhesion of various cells, induces the differentiation of salivary gland acinar cells, stimulates neurite outgrowth, secretion of matrix metalloproteinases and angiogenesis. AG73 retains its angiogenic activity when conjugated to chitosan membranes. AG73 can be used in the research of melanoma and ischemic injury^[1][2][3].

AG73 (200 μg/mL) 可完全抑制小鼠黑色素瘤 (B16F10) 细胞在 Matrigel 上形成细胞网络^[1]。
AG73 可与固定化的生物素化肝素结合，其 K_d 为 6.4 μM^[1]。
AG73 (1-100 μg/mL; 2 天) 可剂量依赖性地刺激孵化 13 天的鸡胚主动脉环的血管出芽^[2]。
AG73 (0.1-100 μg; 18 h) 当以 100 μg 的基质包被浓度使用时，可促进 71% 的 PC12 细胞的轴突生长^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AG73 (每张盖玻片 0.5 μg；局部) 是一种体内血管生成因子，在鸡胚尿囊膜 (CAM) 实验中可使 55.5% 的鸡胚产生阳性血管生成反应^[2]。
AG73 (每只小鼠 1 mg/mL；皮下注射) 可在体内促进血管细胞迁移与血管生成^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1497.82

C₆₄H₁₂₀N₂₄O₁₇

170655-66-0

Arg-Lys-Arg-Leu-Gln-Val-Gln-Leu-Ser-Ile-Arg-Thr

RKRLQVQLSIRT

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hoffman MP, et al. Cell type-specific differences in glycosaminoglycans modulate the biological activity of a heparin-binding peptide (RKRLQVQLSIRT) from the G domain of the laminin alpha1 chain. J Biol Chem. 2001;276(25):22077-22085.  [Content Brief]

  [2]. Mochizuki M, et al. Angiogenic activity of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT). Arch Biochem Biophys. 2007;459(2):249-255.  [Content Brief]

  [3]. Weeks BS, et al. Laminin-1 and the RKRLQVQLSIRT laminin-1 alpha1 globular domain peptide stimulate matrix metalloproteinase secretion by PC12 cells. Exp Cell Res. 1998;243(2):375-382.  [Content Brief]