2. Immunology/Inflammation Antibody-drug Conjugate/ADC Related
  3. Fc Receptor (FcR) Complement System Radionuclide-Drug Conjugates (RDCs)
  4. AKIR001

AKIR001 是一种高亲和力的人源化 IgG1 抗体，靶向 CD44v6。AKIR001 在其 FcγR 结合域携带 LALA 抑制突变，以减少与 FcγR 和 C1q 的相互作用，从而降低组织相互作用并限制补体依赖性细胞毒性 (CDC) 和抗体依赖性细胞介导的细胞毒性 (ADCC) 的风险。[177Lu] 标记的 AKIR001，即 [177Lu]Lu-AKIR001，被发现对表皮样癌具有抗肿瘤活性。

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AKIR001

AKIR001 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

AKIR001 相关抗体

Top Publications Citing Use of Products

查看 Radionuclide-Drug Conjugates (RDCs) 亚型特异性产品:

查看所有亚型
RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AKIR001 is a high-affinity human IgG1 antibody targeting CD44v6. AKIR001 carries LALA-silencing mutations in its FcγR-binding domain to reduce FcγR and C1q interactions, minimizing tissue interactions and limiting CDC and ADCC risks. [177Lu] radiolabeled AKIR001, namely [177Lu]Lu-AKIR001, has anticancer activity against epidermoid carcinoma[1].

反应种属

Human
IC50 & Target

CD44
体外研究
(In Vitro)

AKIR001 在 BxPC-3 细胞中缺乏 CDC 和 ADCC 活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AKIR001 相关抗体:
体内研究
(In Vivo)
基因 ID

960  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
组分

Please refer to the lot-specific COA for specific buffer information.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AKIR001 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKIR001AKIR 001AKIR-001Fc Receptor (FcR)Complement SystemRadionuclide-Drug Conjugates (RDCs)Fc ReceptorMCF-7 cellsFcγRCD44v6C1qCD44v6-expressing xenograft modelsCDCBALB/c nu/nu miceADCCBxPC-3 cellscd44v6-positive solid cancersInhibitorinhibitorinhibit

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产品名称：
AKIR001
目录号：
HY-P991922
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