2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)
  4. ALDH3A1-IN-4

ALDH3A1-IN-4 是一种选择性 ALDH3A1 抑制剂，IC50 为 0.2 μM。ALDH3A1-IN-4 通过疏水作用和范德华力结合于 ALDH3A1 的醛结合口袋。ALDH3A1-IN-4 可作为化学增敏剂，使表达 ALDH3A1 的癌细胞对马磷酰胺的抗增殖作用敏感，但不会使不表达 ALDH3A1 的非癌细胞产生增敏效应。ALDH3A1-IN-4 可用于肺腺癌和胶质母细胞瘤的相关研究。

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ALDH3A1-IN-4

ALDH3A1-IN-4 Chemical Structure

CAS No. : 324777-01-7

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ALDH3A1-IN-4 相关抗体

Top Publications Citing Use of Products

查看 Aldehyde Dehydrogenase (ALDH) 亚型特异性产品:

查看所有亚型
ALDH1 ALDH2 ALDH3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALDH3A1-IN-4 is a selective ALDH3A1 inhibitor with an IC50 of 0.2 μM. ALDH3A1-IN-4 binds to the aldehyde-binding pocket of ALDH3A1 via hydrophobic interactions and van der Waals forces. ALDH3A1-IN-4 acts as a chemosensitizer that sensitizes ALDH3A1-expressing cancer cells to the antiproliferative effect of mafosfamide, but does not produce a sensitizing effect on non-cancer cells that do not express ALDH3A1. ALDH3A1-IN-4 is applicable to research related to lung adenocarcinoma and glioblastoma[1].

IC50 & Target[1]

ALDH3A1

0.2 μM (IC50)

体外研究
(In Vitro)

ALDH3A1-IN-4 (compound CB7) (10 μM; 1 min) 可强效抑制表达 ALDH3A1 的癌细胞裂解物中的 ALDH3A1 活性[1]。
ALDH3A1-IN-4 (10 μM; 19 h) 可选择性地使表达 ALDH3A1 的 A549 和 SF767 癌细胞对马磷酰胺增敏[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ALDH3A1-IN-4 相关抗体:

Cell Proliferation Assay[1]

Cell Line: A549 lung adenocarcinoma, SF767 glioblastoma, CCD-13Lu primary lung fibroblast cell lines
Concentration: 10 μM (in combination with mafosfamide)
Incubation Time: 19 h
Result: Decreased cell proliferation in A549/SF767 cells compared to mafosfamide alone, and no increased chemosensitization was observed in CCD-13Lu cells treated with ALDH3A1-IN-4 and mafosfamide.
分子量

290.31

Formula

C14H11FN2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALDH3A1-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALDH3A1-IN-4324777-01-7Aldehyde Dehydrogenase (ALDH)ALDH1A2ALDH3A1ALDH1A1SF767lung adenocarcinomaALDH1A3A549ALDH1B1glioblastomaALDH2Inhibitorinhibitorinhibit

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