2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage Neuronal Signaling Membrane Transporter/Ion Channel Immunology/Inflammation
  3. Ceramidase PPAR TRP Channel Interleukin Related NEDD8-activating Enzyme
  4. AM9053

AM9053 是一种选择性的、有效且缓慢可逆的 N-酰基乙醇胺酸酰胺酶 (NAAA) 抑制剂 (IC50 = 30 nM)。AM9053 对 FAAH 活性的影响有限 (IC50 > 100 nM)。AM9053 通过激活 PPAR-α 和 TRPV1 依赖性机制抑制结直肠癌细胞增殖，诱导 S 期细胞周期阻滞。AM9053 通过调节巨噬细胞活性和抑制 IL-23 信号通路，减轻肠道纤维化。AM9053 导致 NAE 水平增加，特别是 PEA 和 OEA。AM9053 可用于研究结直肠癌和肠道纤维化。

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AM9053

AM9053 Chemical Structure

CAS No. : 157469-21-1

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规格 价格 是否有货 数量
5 mg ￥1071
3 - 4 周
10 mg ￥1700
3 - 4 周
25 mg ￥3060
3 - 4 周
50 mg ￥4250
3 - 4 周
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

AM9053 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

查看所有亚型
PPARα PPARβ/δ PPARγ PPAR PPARδ

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPA1 TRPC3 TRPC4 TRPC5 TRPM8 TRPM2 TRPM3 TRPM4 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AM9053 is a selective, effective and slowly reversible inhibitor of N-acyl ethanolamine acid amidease (NAAA) (IC50 = 30 nM). The effect of AM9053 on FAAH activity is limited (IC50 > 100 nM). AM9053 inhibits the proliferation of colorectal cancer cells by activating the PPAR-α and TRPV1 dependent mechanisms and induces S-phase cell cycle arrest. AM9053 alleviates intestinal fibrosis by regulating macrophage activity and inhibiting the IL-23 signaling pathway. AM9053 leads to an increase in NAE levels, especially PEA and OEA. AM9053 can be used for the study of colorectal cancer and intestinal fibrosis[1][2][3].

IC50 & Target[2][3]

PPARα

 

TRPV1

 

IL-23

 

分子量

275.45

Formula

C17H25NS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AM9053 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM9053157469-21-1AM 9053AM-9053CeramidasePPARTRP ChannelInterleukin RelatedNEDD8-activating EnzymePeroxisome proliferator-activated receptorsTransient receptor potential channelsILNAENAAA inhibitioncolorectal cancerintestinal fibrosisN-acylethanolaminesPPAR-αTRPV1IL-23 signalingmacrophage modulationanticancer therapyantifibrotic treatmentInhibitorinhibitorinhibit

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目录号：
HY-185011
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