1. 疾病领域
  2. 血液和心脑血管疾病
  3. 心血管疾病 心脏疾病
  4. 心力衰竭
  5. Amisometradine

Amisometradine 是一种口服有效的氨基尿嘧啶类利尿剂,其利尿效力约为 Mersalyl (HY-108868) 的 40% (肌肉注射)。Amisometradine 通过促进钠、氯及少量钾的排泄发挥作用,对心力衰竭模型具有显著疗效且长期给药耐受性良好。Amisometradine 相较于同类药物胃肠道反应更少,少部分副作用主要表现为恶心、呕吐、腹泻及耳鸣耳聋等,通常不伴随蛋白尿或血液尿液指标异常。Amisometradine 是研究心力衰竭及相关利尿机制的重要工具。

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Amisometradine

Amisometradine Chemical Structure

CAS No. : 550-28-7

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  • 生物活性

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生物活性

Amisometradine is an orally active aminouracil diuretic with a diuretic potency approximately 40% that of Mersalyl (HY-108868) (when administered intramuscularly). Amisometradine exerts its effects by promoting the excretion of sodium, chloride and a small amount of potassium, exhibits significant therapeutic effects in heart failure models, and has good tolerance with long-term administration. Compared with drugs of the same class, Amisometradine causes fewer gastrointestinal reactions; its minor side effects mainly include nausea, vomiting, diarrhea, tinnitus and deafness, and are usually not accompanied by proteinuria or abnormalities in blood and urine indicators. Amisometradine is an important tool for the study of heart failure and related diuretic mechanisms[1].

分子量

195.22

Formula

C9H13N3O2

CAS 号
性状

固体

中文名称

阿米美啶

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
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参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Amisometradine
目录号:
HY-124470
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