2. Immunology/Inflammation
  3. Interleukin Related
  4. AMY109

AMY109 是一种抗人白细胞介素-8 (IL-8)单克隆抗体，针对人 IL-8 的 IC50 值为 0.14 μg/mL 和 0.37 μg/mL，与人 IL-8 结合的 Ka 为 36.8 pM，与食蟹猴 IL-8 结合的 Ka 为 380 pM。\nAMY109 以 pH 依赖的方式结合人及食蟹猴 IL-8，可抑制 IL-8 介导的 CXCR1 和 CXCR2 活化，并阻断 IL-8 的下游生物学活性。AMY109 可抑制中性粒细胞向子宫内膜异位病灶募集，并抑制中性粒细胞产生单核细胞趋化蛋白-1。AMY109 适用于子宫内膜异位症相关研究。

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AMY109

AMY109 Chemical Structure

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AMY109 相关抗体

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查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMY109 is an anti-human interleukin-8 (IL-8) monoclonal antibody, with IC50 values of 0.14 μg/mL and 0.37 μg/mL against human IL-8, a Ka of 36.8 pM for human IL-8, and a Ka of 380 pM for cynomolgus monkey IL-8.\nAMY109 binds to human and cynomolgus monkey IL-8 in a pH-dependent manner, inhibits IL-8-mediated activation of CXCR1 and CXCR2, and blocks the downstream biological activities of IL-8. AMY109 inhibits neutrophil recruitment to endometriotic lesions and suppresses monocyte chemoattractant protein-1 production by neutrophils. AMY109 is applicable to research related to endometriosis[1].

反应种属

Human
体外研究
(In Vitro)

AMY109 (pH 7.4; pH 5.8) 对人源 IL-8 表现出高结合亲和力，在中性条件下对食蟹猴 IL-8 表现出较弱但可检测到的结合亲和力，且在内涵体 pH 下会以 pH 依赖的方式与人源 IL-8 解离[1]。
AMY109 可在基于细胞的实验中强效中和 IL-8 依赖的 CXCR1 和 CXCR2 活化[1]。
AMY109 (600 ng/mL IL-8) 可有效抑制 IL-8 诱导的人食蟹猴中性粒细胞趋化作用[1]。
AMY109 可抑制 IL-8 诱导的人中性粒细胞迁移以及 IL-8 刺激人中性粒细胞产生 MCP-1[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AMY109 相关抗体:
体内研究
(In Vivo)

AMY109 (2-10 mg/kg; subcutaneous injection; every 4 weeks; 6 months) 可稳定疾病进展、缩小结节病灶体积、诱导子宫内膜异位病灶发生萎缩性改变、减少纤维化，并降低手术诱导子宫内膜异位症的食蟹猴的术后粘连[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Macaca fascicularis (female, reproductive age 8 to 14 years old, surgically induced endometriosis)[1]
Dosage: 2 mg/kg (maintenance dose; preceded by a 3 mg/kg loading dose); 10 mg/kg
Administration: subcutaneous injection; every 4 weeks; 6 months
Result: Maintained modified r-ASRM score stable, while it significantly increased in vehicle-treated monkeys.
Reduced relative volume of nodular lesions.
Induced atrophy of endometrial epithelium in 55% of evaluable sites (2 mg/kg) and 54% of evaluable sites (10 mg/kg).
Induced atrophy/decreased stromal cells in 33% of evaluable sites (2 mg/kg) and 60% of evaluable sites (10 mg/kg).
Decreased fibrotic interstitium in 34% of evaluable sites (2 mg/kg) and 61% of evaluable sites (10 mg/kg).
Reduced hemosiderin deposition compared to vehicle.
Produced marked reduction in postsurgical incision adhesions in 6 of 7 monkeys treated with 10 mg/kg.
Achieved greater lesion volume reduction in monkeys without antidrug antibodies (ADAs) than those with ADAs.
基因 ID

3576  [NCBI]

Accession
靶点

CXCL8/IL-8
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AMY109 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMY109AMY 109AMY-109Interleukin RelatedILCXCR1endometriosisendometriotic lesionscynomolgus monkeyinterleukin-8neutrophilsIL-8monocyte chemoattractant protein-1neutrophil recruitmentCXCR2Inhibitorinhibitorinhibit

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