2. Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Bacterial Reactive Oxygen Species (ROS)
  4. Antibacterial agent 325

Antibacterial agent 325 是一种抗菌 (antibacterial) 剂。Antibacterial agent 325 具有强效广谱抗菌活性，且表现出杀菌活性。Antibacterial agent 可诱导膜去极化，破坏膜完整性，提高活性氧 (ROS) 生成水平与脂质过氧化水平。Antibacterial agent 325 可抑制代谢活性与 LDH 活性。Antibacterial agent 325 在细菌中诱导耐药性的能力弱，同时具有低溶血活性与低细胞毒性。Antibacterial agent 325 可用于细菌感染的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Antibacterial agent 325

Antibacterial agent 325 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Antibacterial agent 325 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 325 is an antibacterial agent. Antibacterial agent 325 exerts potent broad-spectrum antibacterial activity and shows bactericidal activity. Antibacterial agent induces membrane depolarization, disrupts the membrane integrity, increasess ROS production and lipid peroxidation levels. Antibacterial agent 325 inhibits the metabolic activity and LDH activity. Antibacterial agent 325 exhibits low drug resistance development in bacteria, low hemolysis and cytotoxicity. Antibacterial agent 325 can be used for the research of bacterial infection[1].

体外研究
(In Vitro)

Antibacterial agent 325 (Compound 14a) 具有强效的广谱体外抗菌活性，对耐甲氧西林的 Staphylococcus aureus (MIC = 0.25 μg/mL)、Escherichia coli (MIC = 0.25 μg/mL)、Klebsiella pneumonia (MIC = 0.5 μg/mL) 和 Acinetobacter
baumannii (MIC = 0.5 μg/mL) 的功效尤为显著[1]。
Antibacterial agent 325 (0.5-128 μg/mL) 对人红细胞表现出极低的溶血活性，在最高达 128 μg/mL 的测试浓度范围内溶血率均低于 3%[1]。
Antibacterial agent 325 (10-100 μg/mL; 24 h) 对人 LO2 肝细胞表现出低细胞毒性[1]。
Antibacterial agent 325 与 Norfloxacin (HY-B0132) 联用，在体外对 E. coli 和 MRSA 均表现出协同抗菌活性，两种菌株对应的 FICI 均为 0.25[1]。
Antibacterial agent 325 (0.25-1 μg/mL; 12 h) 对 MRSA 表现出快速杀菌活性，在 4× MIC 浓度下可于 12 h 内完全清除该菌株[1]。
Antibacterial agent 325 (16 days) 诱导 MRSA 耐药的潜力较低，在 16 次连续传代过程中未观察到 MIC 升高[1]。
Antibacterial agent 325 (0.25-1 μg/mL; 10-30 min) 可诱导 MRSA 发生显著的、时间依赖性的膜去极化[1]。
Antibacterial agent 325 (0.25-1.5 μg/mL) 以剂量依赖方式破坏 MRSA 的膜完整性；其表现为 PI 摄取增加和钙黄绿素-AM (calcein-AM) 滞留量降低[1]，。
Antibacterial agent 325 (0.25-2 μg/mL) 可导致 MRSA 呈剂量依赖性的蛋白泄漏[1]。
Antibacterial agent 325 (0.25-2.5 μg/mL; 30-150 min) 可在 MRSA 中诱导呈剂量依赖性和时间依赖性 ROS 生成[1]。
Antibacterial agent 325 (0.25-2 μg/mL) 可在 MRSA 中诱导剂量依赖性脂质过氧化[1]。
Antibacterial agent 325 (0.25-2 μg/mL) 会破坏 MRSA 的抗氧化防御系统，导致 GSH 活性呈剂量依赖性丧失[1]。
Antibacterial agent 325 (2 μg/mL; 6 h) 会导致 MRSA 出现可见的形态损伤与皱缩，表明细胞膜发生破坏[1]。
Antibacterial agent 325 (0.25-2 μg/mL) 可剂量依赖性地抑制 MRSA 的代谢活性[1]。
Antibacterial agent 325 (0.25-2 μg/mL) 可剂量依赖性地抑制 MRSA LDH 活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 325 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: LO2 human hepatocytes
Concentration: 10-100 μg/mL
Incubation Time: 24 h
Result: Maintained cell survival rates exceeding 90% at bactericidal concentrations, with survival rates remaining above 60% even at 100 μg/mL.

Immunofluorescence[1]

Cell Line: MRSA
Concentration: 0.5 μg/mL
Incubation Time: 6 h
Result: Increased fluorescence of DCFH-DA.
体内研究
(In Vivo)

Antibacterial agent 325 (Compound 14a) (0.100 mg/kg；局部给药； 48 小时一次；2 剂) 在小鼠伤口耐甲氧西林金黄色葡萄球菌感染模型可抑制细菌感染引发的炎症反应，并促进伤口愈合[1]。
Antibacterial agent 325 (0.067-0.1 mg/kg) 可提高感染耐甲氧西林金黄色葡萄球菌的大蜡螟幼虫存活率[1].。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MRSA-infected ICR mice (wound infection model)[1]
Dosage: 0.100 mg/kg
Administration: Topical administration
Result: Reduecd neutrophils levels.
Reduced mouse wound relative area to near 0% by day 7 at 0.100 mg/kg, comparable to ciprofloxacin at 0.400 mg/kg.
分子量

469.94

Formula

C25H25ClFN3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 325 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 325Antibacterial agent325Antibacterial agent-325BacterialReactive Oxygen Species (ROS)bacterial wound infectionK. p.bacterial metabolismDNA replicationA. b.bacterial DNAbacterial lactate dehydrogenaseMRSAE. c.LO2 human hepatocytesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Antibacterial agent 325
目录号：
HY-181677
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z