2. Metabolic Enzyme/Protease
  3. MetAP
  4. Anticancer agent 313

Anticancer agent 313 是一种 MetAP2 抑制剂，IC50 为 4.11 μM。Anticancer agent 313 可通过非经典的 mTORC1 依赖性通路激活转录因子 ATF4。Anticancer agent 313 能够抑制癌细胞增殖。Anticancer agent 313 可用于乳腺癌、胰腺癌的研究。

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Anticancer agent 313

Anticancer agent 313 Chemical Structure

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Anticancer agent 313 相关抗体

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MetAP2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 313 is a MetAP2 inhibitor with an IC50 of 4.11 μM. Anticancer agent 313 activates the transcription factor ATF4 via a non-canonical mTORC1-dependent pathway. Anticancer agent 313 inhibits cancer cell proliferation. Anticancer agent 313 is applicable to the research of breast cancer and pancreatic cancer[1].

IC50 & Target[1]

MetAp2

 

体外研究
(In Vitro)

Anticancer agent 313 (compound 3) (72 h) 可抑制 67nr、4T1、MDA-MB-231、BxPC3 和 MIA PaCa-2 癌细胞系的增殖[1]。
Anticancer agent 313 可通过 mTORC1 依赖的非经典 (eIF2α 磷酸化非依赖) 机制在 67nr、MDA-MB-231 和 MIA PaCa-2 癌细胞系中诱导 ATF4 表达，但在 4T1 细胞中无此作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 313 相关抗体:

Cell Viability Assay[1]

Cell Line: 67nr, 4T1, MDA-MB-231, BxPC3, MIA PaCa-2 cells
Concentration: /
Incubation Time: 72 h
Result: Had IC50 values of 14.4 (67nr), 2.76 (4T1), 17.32 (MDA-MB-231), 16.7 (BxPC3), 9.71 (MIA PaCa-2) μM.
分子量

346.50

Formula

C18H26N2O3Si
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 313 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 313Anticancer agent313Anticancer agent-313MetAPMethionine AminopeptidaseMetAP2mTORC1breast cancer4T1eIF2α phosphorylationBxPC3pancreatic cancerATF467nrMDA-MB-231Inhibitorinhibitorinhibit

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产品名称：
Anticancer agent 313
目录号：
HY-182781
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