2. Apoptosis Others NF-κB Stem Cell/Wnt
  3. Apoptosis Drug Derivative NF-κB Wnt
  4. Antiproliferative agent-76

Antiproliferative agent-76 (Compound II-2) 是一种 8-sulfonamidoquinolin 衍生物，同时也是选择性抗癌剂。Antiproliferative agent-76 能够阻断 NF-κB 和 WNT 信号通路。Antiproliferative agent-76 可促进癌细胞凋亡 (Apoptosis)。Antiproliferative agent-76 对结直肠癌、白血病具有抗癌活性。

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Antiproliferative agent-76

Antiproliferative agent-76 Chemical Structure

CAS No. : 33757-62-9

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Antiproliferative agent-76 相关抗体

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiproliferative agent-76 (Compound II-2) is an 8-sulfonamidoquinoline derivative and a selective anticancer agent. Antiproliferative agent-76 blocks the NF-κB and WNT signaling pathways. Antiproliferative agent-76 promotes cancer cell Apoptosis. Antiproliferative agent-76 exhibits anticancer activity against colorectal cancer and leukemia[1].

体外研究
(In Vitro)

Antiproliferative agent-76 (10 μM; 48 h) 可强效抑制 HCT116 结直肠癌细胞的增殖，其 IC50 为 1.0 ± 0.13 μM[1]。
Antiproliferative agent-76 (10 μM; 48 h) 可抑制 HT-29 结直肠癌细胞的增殖，其 IC50 为 5.3 ± 0.84 μM[1]。
Antiproliferative agent-76 (10 μM; 48 h) 可抑制 Mv4;11 髓系白血病细胞的增殖，其 IC50 为 7.6 ± 0.65 μM[1]。
Antiproliferative agent-76 (10 μM) 可选择性抑制 8 种癌细胞系的增殖 (10 μM 时抑制率 >80%)，同时对正常 786-O 和 L-02 细胞活性较低[1]。
Antiproliferative agent-76 (1.25-5 μM; 48 h) 可浓度依赖性地诱导 HCT116 结直肠癌细胞发生凋亡，在 5 μM 处理 48 h 后凋亡率可达 80%[1]。
Antiproliferative agent-76 (II-2) (1.25-2.5 μM; 48 h) 可浓度依赖性地诱导 HCT116 结直肠癌细胞发生 G2/M 期细胞周期阻滞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antiproliferative agent-76 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Mv4;11 myeloid leukemia cells
Concentration: 10 μM
Incubation Time: 48 h
Result: Achieved 53 ± 8.0% proliferation inhibition at 10 μM.
Reached an IC50 value of 7.6 ± 0.65 μM.

Cell Cycle Analysis[1]

Cell Line: HCT116 colorectal cancer cells
Concentration: 1.25-2.5 μM
Incubation Time: 48 h
Result: Caused significant accumulation of cells in the G2 phase in a concentration-dependent manner.
Decreased the percentage of cells in the G1 phase in a concentration-dependent manner.
分子量

329.33

Formula

C15H11N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiproliferative agent-76 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antiproliferative agent-7633757-62-9Antiproliferative agent76Antiproliferative agent 76ApoptosisDrug DerivativeNF-κBWntDrug derivativeNuclear factor-κBNuclear factor-kappaBNF-κB signaling pathwaysHT-29 colorectal cancer cellsIκBαWNT/β-catenin signaling pathwaysHCT116 colorectal cancer cellsL-02 cellscolorectal cancerMv4;11 myeloid leukemia cellsSKA cellsP65Inhibitorinhibitorinhibit

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