2. Anti-infection
  3. Bacterial
  4. Antitubercular agent-57

Antitubercular agent-57 是一种选择性抗分枝杆菌剂，对包括肝细胞系在内的哺乳动物细胞系的体外毒性较低。Antitubercular agent-57 对药物敏感型、耐多药型和广泛耐药型结核分枝杆菌菌株均具有活性，与一线或二线抗结核剂无交叉耐药性。Antitubercular agent-57 对革兰氏阳性菌、革兰氏阴性菌和真菌菌株均无活性。Antitubercular agent-57 可用于结核病、耐多药结核病的研究。

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Antitubercular agent-57

Antitubercular agent-57 Chemical Structure

CAS No. : 461431-74-3

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Antitubercular agent-57 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitubercular agent-57 is a selective antimycobacterial agent with low in vitro toxicity against mammalian cell lines including hepatocyte cell lines. Antitubercular agent-57 exhibits activity against drug-sensitive, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains, and shows no cross-resistance with first-line or second-line antitubercular agents. Antitubercular agent-57 has no activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. Antitubercular agent-57 can be used in the research of tuberculosis and multidrug-resistant tuberculosis[1].

体外研究
(In Vitro)

Antitubercular agent-57 (compound 10) (0.03-1000 μM; 7-21 d) 可强效抑制药物敏感型和耐多药型结核分枝杆菌、堪萨斯分枝杆菌及鸟分枝杆菌的生长，其中对药物敏感型和耐多药型结核分枝杆菌的 MIC 为 0.25 μM[1]。
Antitubercular agent-57 (0.488-500 μM; 24-120 h) 对受试酵母和霉菌菌株无体外抗真菌活性，其 MIC 值>500 μM[1]。
Antitubercular agent-57 (0.488-500 μM; 24-48 h) 对受试的革兰氏阳性和革兰氏阴性菌株表现出极低的体外抗菌活性，其 MIC 值 ≥250 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitubercular agent-57 相关抗体:

Cell Viability Assay[1]

Cell Line: HuH7 (human hepatocellular carcinoma), A431 (human epidermoid carcinoma), MDCK (Madin-Darby canine kidney), HepG2 (human hepatocellular carcinoma)
Concentration: 30 μM
Incubation Time: 48 h
Result: Resulted in relative cell viability of 137% (HuH7) compared to vehicle-treated controls.
Resulted in relative cell viability of 90% (A431) compared to vehicle-treated controls.
Resulted in relative cell viability of 84% (MDCK) compared to vehicle-treated controls).
Resulted in relative cell viability of 145% (HepG2) compared to vehicle-treated controls.
Yielded a selectivity index (SI=IC50(HepG2)/MIC(M.
tuberculosis)) of >120.
分子量

276.29

Formula

C13H16N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitubercular agent-57 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitubercular agent-57461431-74-3Antitubercular agent57Antitubercular agent 57Bacterialgram-positive bacteriaextensively drug-resistant strainsMycobacterium tuberculosisfungal strainsHuH7HepG2multidrug-resistant tuberculosisgram-negative bacteriaM. aviumM. kansasiiInhibitorinhibitorinhibit

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