2. Immunology/Inflammation
  3. Interleukin Related
  4. APG808

APG808 是一种抗人源 IL-4Rα 单克隆抗体。APG808 可结合 IL-4Rα，阻止 IL-13Rα1/IL-4Rα 异二聚体形成，并阻断由 IL-13 和 IL-4 介导的信号通路。APG808 可消除 Fc 段和补体效应功能。APG808 可用于慢性阻塞性肺疾病、哮喘、特应性皮炎的相关研究。

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APG808

APG808 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
1 mg   询价  
5 mg   询价  
10 mg   询价  

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Customer Review

APG808 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

APG808 is an anti-human IL-4Rα monoclonal antibody. APG808 binds to IL-4Rα, prevents IL-13Rα1/IL-4Rα heterodimer formation, and disrupts IL-13 and IL-4 mediated signaling. APG808 ablates Fc and complement effector functions. APG808 can be used for the research of chronic obstructive pulmonary disease, asthma, atopic dermatitis[1].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
体外研究
(In Vitro)

APG808 在 pH 6.0 条件下对人源 FcRn 具有高亲和力，对人源 FcγRI、FcγRIIIa (F158) 和 FcγRIIIa (V158) 的亲和力降低，且无法检测到与人源 FcγRIIa (H131)、FcγRIIa (R131)、FcγRIIIb 或 C1q 的结合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

APG808 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route AUC0-inf CL Vss Bioavailability T1/2
Cynomolgus Monkey[1] 25.9 mg/kg s.c. 9.77 × 106 ng·h/mL 2.79 101.80 mL/kg 97.51 % 27.18
基因 ID

3566  [NCBI]

Accession
靶点

IL-4Ra/CD124
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

APG808 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APG808PR001APG 808APG-808PR 001PR-001Interleukin RelatedILInterleukin-4 receptor-alpha chainasthmachronic obstructive pulmonary diseaseIL-13neonatal Fc receptorIL-4RαIL-13Rα1/IL-4Rα heterodimerIL-4FcRncynomolgus monkeysInhibitorinhibitorinhibit

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产品名称：
APG808
目录号：
HY-P992034
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