2. Epigenetics PI3K/Akt/mTOR Apoptosis
  3. AMPK Apoptosis
  4. ASS1 activator 1

ASS1 activator 1 (Compound 10f) 是一种 ASS1 激活剂，EC50 为 1.90 μM。ASS1 activator 1 可增强 ASS1 的活性，增强 AMPK 磷酸化。ASS1 activator 1 可诱导细胞凋亡 (Apoptosis)。ASS1 activator 1 对三阴性乳腺癌、结直肠癌和肝癌具有抗癌活性。

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ASS1 activator 1

ASS1 activator 1 Chemical Structure

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ASS1 activator 1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ASS1 activator 1 (Compound 10f) is a ASS1 activator with an EC50 of 1.90 μM. ASS1 activator 1 enhances the activity of ASS1 and promotes AMPK phosphorylation. ASS1 activator 1 induces cell Apoptosis. ASS1 activator 1 exhibits anticancer activity against triple-negative breast cancer, colorectal cancer and liver cancer[1].

体外研究
(In Vitro)

ASS1 activator 1 可强效激活重组 ASS1 蛋白，其 EC50 为 1.90 μM[1]。
ASS1 activator 1 (48 h) 可抑制多种人类癌细胞系 (HT-29、HepG2、MDA-MB-231、T47D、MCF-7、SK-BR-3) 的活力，其 IC50 值范围为 1.9 至 14.4 μM；而对正常 MCF-10A 乳腺上皮细胞的活性较低，IC50 为 28.5 μM[1]。
ASS1 activator 1 (2-8 μM; 24 h) 可以浓度依赖的方式抑制 MDA-MB-231 三阴性乳腺癌细胞的迁移[1]。
ASS1 activator 1 (5 μM；在 37 °C 下孵育至达到平衡) 具有较高的血浆蛋白结合率，在 5 μM 条件下人血浆中的结合率为 98.3%，大鼠血浆中的结合率为 96.3%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ASS1 activator 1 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 2 μM, 4 μM, 8 μM
Incubation Time: 18 h
Result: Upregulated p-AMPK levels in a concentration-dependent manner without affecting total AMPK or ASS1 levels.
Decreased SQSTM/p62 levels and increased LC3B-II levels, indicating increased autophagic flux.
药代动力学
(Parmacokinetics)
Species Dose Route Cmax Tmax T1/2 AUC0-t AUC0-∞ CL Vz Vss MRT0-∞ Bioavailability
Rat[1] 1 mg/kg i.v. 263 ± 34.3 ng/mL 0.10 ± 0.00 h 6.32 ± 0.34 h 619 ± 79.6 ng·h/mL 654 ± 86.3 ng·h/mL 1.55 ± 0.21 L/h/kg 14.1 ± 1.37 L/kg 10.0 ± 1.30 L/kg 6.47 ± 0.25 h /
Rat[1] 5 mg/kg p.o. 53.5 ± 3.61 ng/mL 4.0 ± 0.00 h 5.00 ± 0.69 h 538 ± 30.8 ng·h/mL 562 ± 41.1 ng·h/mL / / / 7.89 ± 0.72 h 17.4 %
体内研究
(In Vivo)

ASS1 activator 1 (5 mg/kg；腹腔注射；每 2 天 1 次) 对裸鼠体内的 MDA-MB-231 三阴性乳腺癌异种移植物发挥强效的抗增殖作用，且无全身毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (female, 4−6 weeks old)[1]
Dosage: 5 mg/kg
Administration: intraperitoneally; every other day; 23 days
Result: Reduced final tumor weights and tumor volumes significantly compared to vehicle control.
Decreased Ki67-positive cells (cell proliferation marker) significantly in tumor tissue relative to controls.
Increased LC3B levels (autophagy marker) significantly in tumor tissue relative to controls.
Caused no significant changes in mouse body weight.
Showed no pathological changes in major organs (heart, liver, spleen, lung, kidney) via H&E staining, indicating no apparent systemic toxicity.
分子量

743.97

Formula

C41H65N3O9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ASS1 activator 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASS1 activator 1AMPKApoptosisAMP-activated protein kinaseAMPK/mTOR signaling pathwayMCF-10AHepG2argininosuccinate synthase 1MCF-7MDA-MB-231T47DHT-29tumor cell apoptosistriple-negative breast cancerInhibitorinhibitorinhibit

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ASS1 activator 1
目录号：
HY-181832
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