2. Cell Cycle/DNA Damage
  3. Wee1
  4. BAA-065

BAA-065 是一种选择性且具有口服活性的 PKMYT1 抑制剂，其 IC50 小于 50 nM。BAA-065 可抑制癌细胞增殖，诱导 γH2AX 表达及 DNA 损伤。BAA-065 在 OVCAR3 异种移植小鼠模型中可抑制肿瘤生长。BAA-065 可用于癌症研究，如卵巢癌。

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BAA-065

BAA-065 Chemical Structure

1.  客户无需承担相应的运输费用。

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3.  试用装只面向终端客户。

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BAA-065 相关抗体

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PKMYT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BAA-065 is a selective and orally active PKMYT1 inhibitor with an IC50 of <50 nM. BAA-065 inhibits cancer cells proliferation, induces γH2AX expression and DNA damage. BAA-065 inhibits tumor growth in OVCAR3 xenograft mice. BAA-065 can be used for the research of cancer, such as ovarian cancer[1].

IC50 & Target[1]

PKMYT1

<sup>[1]</ nM (IC50)

体外研究
(In Vitro)

BAA-065 (6-500 nM) 可在多种敏感癌细胞系中选择性诱导 γH2AX 表达，在 OVCAR3 细胞中与拓扑异构酶 1 抑制剂 SN38 (HY-13704) 联用可调控细胞周期进程和 DNA 损伤相关的细胞生物标志物，并在 HCC1596 乳腺癌细胞系中影响细胞周期进程相关生物标志物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BAA-065 相关抗体:
体内研究
(In Vivo)

BAA-065 (160 mg/kg；口服；每日一次，连续给药 18 天) 可在人卵巢癌 OVCAR3 异种移植小鼠模型中抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human ovarian cancer OVCAR3 xenograft mice models[1]
Dosage: 160 mg/kg
Administration: p.o.; qd for 18 days
Result: Inhibited tumor growth.
Showed stronger antitumor activity combined with antibody-drug conjugate bearing topoisomerase 1 inhibitor payload.
分子量

497.61

Formula

C25H31N5O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BAA-065 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAA-065BAA065BAA 065Wee1Inhibitorinhibitorinhibit

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目录号：
HY-182790
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