2. Others Protein Tyrosine Kinase/RTK
  3. Isotope-Labeled Compounds TAM Receptor
  4. Bemcentinib-d8

Bemcentinib-d8 (R428-d8) 是氘代标记的 Bemcentinib (HY-15150)。Bemcentinib (R428) 是一种选择性具有口服活性的 Axl 抑制剂，IC50 为 14 nM。Bemcentinib 可抑制癌细胞迁移和侵袭。在细胞中，Bemcentinib 对 Axl 的选择性是 Abl 的 100 倍以上，对 TAM 家族激酶 Mer 和 Tyro3 的选择性分别为 50 倍和 100 倍以上。Bemcentinib 可阻断转移性乳腺癌模型中的肿瘤扩散并延长生存期。

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Bemcentinib-d<sub>8</sub>

Bemcentinib-d8 Chemical Structure

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Other Forms of Bemcentinib-d8:

Bemcentinib-d8 相关抗体

Top Publications Citing Use of Products

查看 TAM Receptor 亚型特异性产品:

查看所有亚型
Axl Mer Tyro3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bemcentinib-d8 (R428-d8) is the deuterium labeled Bemcentinib (HY-15150). Bemcentinib (R428) is a selective and orally active Axl inhibitor with an IC50 of 14 nM. Bemcentinib retards cancer cell migration and invasion. Bemcentinib exhibits >100-fold selectivity for Axl versus Abl and 50- and >100-fold selectivity over TAM family kinases Mer and Tyro3, respectively, in cells. Bemcentinib blocks tumor spread and prolongs survival in models of metastatic breast cancer[1][2].

产品应用

1. 该化合物可作为示踪剂。
2. 该化合物可作为 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。
体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bemcentinib-d8 相关抗体:
分子量

514.69

Formula

C30H26D8N8
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bemcentinib-d8 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bemcentinib-d8R428-d8 BGB324-d8Isotope-Labeled CompoundsTAM ReceptorTyro3AxlMerInhibitorinhibitorinhibit

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目录号：
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