2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Mitochondrial Metabolism
  4. β-carboline-ACS81

β-carboline-ACS81 是一种具有强效抗肿瘤特性的 β-carboline 衍生物。β-carboline-ACS81 通过线粒体膜电位崩溃诱导 HL-60 细胞凋亡 (apoptosis)，并使细胞周期阻滞于 G2/M 期。β-carboline-ACS81 对 HL-60 细胞具有显著的抗增殖活性 (IC50 = 1.52 μM)。β-carboline-ACS81 可用于白血病、组织细胞淋巴瘤、肝细胞癌、恶性黑色素瘤、结直肠癌和肺癌的研究。

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β-carboline-ACS81

β-carboline-ACS81 Chemical Structure

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β-carboline-ACS81 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-carboline-ACS81 is a β-carboline derivative with potent antitumor properties. β-carboline-ACS81 induces apoptosis through the collapse of mitochondrial membrane potential and arrests cell cycle at G2/M phase in HL-60 cells. β-carboline-ACS81 possesses potent antiproliferative activity against HL-60 cells (IC50 = 1.52 μM). β-carboline-ACS81 can be used for the research of leukemia, histiocytic lymphoma, hepatocellular carcinoma, malignant melanoma, colorectal carcinoma and lung carcinoma[1].

体外研究
(In Vitro)

β-carboline-ACS81 (Compound 12c) (72 小时) 对多种肿瘤细胞系表现出显著的抗增殖活性，对 HL-60、U937、HepG2、HCT-116、A375 和 A549 细胞的 IC50 值分别为 1.52、2.03、2.8、6.04、6.57 和 37.23 μM，而对正常 L-02 细胞的 IC50 值为 33.92 μM[1]。
β-carboline-ACS81 (0.38-1.52 μM, 48 小时) 可诱导 HL-60 细胞发生 G2/M 期阻滞，从而抑制细胞增殖并诱发细胞凋亡，线粒体膜电位降低的结果表明，其诱导 HL-60 细胞凋亡的作用可能通过线粒体途径介导[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-carboline-ACS81 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HL-60 cells
Concentration: 0.38, 0.76 and 1.52 μM
Incubation Time: 48 h
Result: Induced a gradual increase in the proportion of cells in the G2/M phase with the rising concentrations.
Elevated G2/M phase cell percentage from 18.75% in the blank control group to 20.58%, 25.63%, and ultimately to 31.28%.
Caused a continuous decrease in the number of cells in the G1 phase, which dropped from 65.97% in the blank control group to 61.82%, 58.39%, and 50.82%, respectively.
Induced little effect on the number of cells in the S phase, which remained largely unchanged.

Apoptosis Analysis[1]

Cell Line: HL-60 cells
Concentration: 0.38, 0.76 and 1.52 μM
Incubation Time: 48 h
Result: Induced progressive chromatin condensation and cell membrane disruption in correlation with the concentration.
Preserved normal nuclear morphology in most cells but induced increased fluorescence (early chromatin condensation) in some cells at 0.38 μM.
Induced intense nuclear fluorescence (pyknosis) in numerous cells and clear nuclear fragmentation into variable bright blue particles (apoptotic bodies) at 0.76 μM.
Eliminated normal nuclear morphology, with most cells showing advanced nuclear pyknosis and karyorrhexis that formed dense, intensely fluorescent blue granular aggregates at 1.52 μM.
Caused a dose-dependent increase in apoptotic cells to 14.73%, 27.68%, and 40.89% at escalating concentrations.
分子量

477.64

Formula

C26H27N3O2S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

β-carboline-ACS81 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-carboline-ACS81ApoptosisMitochondrial Metabolismβ-CarbolineACS81Antitumor activityLeukemiahistiocytic lymphomahepatocellular carcinomacolorectal carcinomamalignant melanomalung carcinomaInhibitorinhibitorinhibit

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