2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. CA1001

CA1001 是一种小分子 ZNF74 抑制剂，同时也是一种外周限制性 κ/δ 双阿片受体 (Opioid Receptor) 激动剂。CA1001 在体外和体内均显示出强大的抗肿瘤活性。CA1001 与免疫检查点抑制剂显著增强肿瘤消退。CA1001 可激活外周限制性 κ/δ 双阿片受体，在炎症性疼痛、神经病理性疼痛、机械痛觉过敏状态下发挥镇痛作用。CA1001 可用于黑色素瘤、机械痛觉过敏、神经病理性疼痛以及炎症性关节炎疼痛的相关研究。

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CA1001

CA1001 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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3.  试用装只面向终端客户。

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Customer Review

CA1001 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CA1001 is a small-molecule ZNF74 inhibitor and a peripherally restricted κ/δ dual opioid receptor agonist. CA1001 exhibits potent antitumor activity both in vitro and in vivo. CA1001, in combination with immune checkpoint inhibitors, significantly enhances tumor regression. CA1001 activates peripherally restricted κ/δ dual opioid receptors and exerts analgesic effects under conditions of inflammatory pain, neuropathic pain, and mechanical hyperalgesia. CA1001 can be used in research related to melanoma, mechanical hyperalgesia, neuropathic pain, and inflammatory arthritis pain.

反应种属

Human
体外研究
(In Vitro)

CA1001 一种小分子 ZNF74 抑制剂，在黑色素瘤细胞系中展现出强效抗肿瘤活性[1]。
CA1001 是一种小分子 ZNF74 抑制剂，与免疫检查点抑制剂联用时可发挥协同作用，显著增强黑色素瘤细胞系中的肿瘤消退效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CA1001 相关抗体:
体内研究
(In Vivo)

CA1001 (1 mg/kg) 在福尔马林诱导的痛觉过敏小鼠中减轻急性反应[2]。
CA1001 (1-10 mg/kg, i.p., once) 在 2 小时和 4 小时显著逆转了机械痛觉过敏在 10 mg/kg[2]。
CA1001 (1-10 mg/kg, i.p., once) 显著提高了爪压迫阈值，逆转了 Complete Freund's adjuvant (CFA) (HY-153808) 诱导的机械性痛觉过敏[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[2]
Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg
Administration: i.p., once
Result: Significantly reversed mechanical hyperalgesia at 10 mg/kg at 2 h and 4 h.
Animal Model: Rat[2]
Dosage: 1 mg/kg, 5 mg/kg, 10 mg/k
Administration: i.p., once
Result: Significantly increased paw withdrawal threshold and reverses Complete Freund's adjuvant (CFA) (HY-153808)-induced mechanical hyperalgesia.
基因 ID

2811  [NCBI]

Accession

P07359
靶点

CD42b/GP1BA
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CA1001 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CA1001CA 1001CA-1001Opioid ReceptorZNF74 inhibitor/κ/δ dual opioid receptor agonistmelanoma cell linesRatmelanomamechanical hyperalgesianeuropathic paininflammatory arthritis painInhibitorinhibitorinhibit

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目录号：
HY-P992012
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