2. Metabolic Enzyme/Protease
  3. Amine N-methyltransferase
  4. CC-410

CC-410 是一种选择性烟酰胺 N-甲基转移酶 (NNMT) 抑制剂，对人源靶点的 IC50 值为 1.6 µM。CC-410 通过糖皮质激素信号网络失调阻碍脂肪细胞终末分化，抑制脂肪生成与脂质积累，其时间敏感性活性仅局限于脂肪生成的早期阶段。CC-410 可用于早发性肥胖、糖皮质激素诱导性肥胖的相关研究。

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CC-410

CC-410 Chemical Structure

CAS No. : 636564-27-7

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CC-410 相关抗体

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NNMT

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CC-410 is a selective Nicotinamide N-methyltransferase (NNMT) inhibitor with a human IC50 value of 1.6 µM. CC-410 impairs terminal adipocyte differentiation via glucocorticoid signaling network deregulation, inhibits adipogenesis and lipid accumulation with time-sensitive activity limited to early adipogenesis stages. CC-410 can be used for the researches of early-onset obesity, glucocorticoid-induced obesity[1].

IC50 & Target[1]

NNMT

1.6 μM (IC50)

体外研究
(In Vitro)

CC-410 可强效抑制 HEK293 细胞中的人源 NNMT 活性，其 IC50 值为 1.6 μM[1]。
CC-410 对 NNMT 具有高度特异性，仅在远高于其 NNMT IC50 的浓度下对 PRMT3、SET1b 复合物和 SMYD2 表现出微弱的抑制作用[1]。
CC-410 (1-25 μM; 48 h) 在浓度高达 25 μM 时对 3T3-L1 前脂肪细胞表现出极低的细胞毒性[1]。
CC-410 (5-25 μM) 在分化早期给药时会抑制 3T3-L1 前脂肪细胞的终末脂肪生成，25 μM 可使脂质积累减少约 80%，但在分化早期之后给药则无作用[1]。
CC-410 (25 μM) 可在分化早期给药或在整个分化阶段持续给药时损伤 C3H10T1/2 小鼠胚胎干细胞前体细胞的终末脂肪生成，证实其具有细胞类型非依赖性机制[1]。
CC-410 会损害 3T3-L1 细胞中糖皮质激素介导的前脂肪细胞启动，在 Dexamethasone (HY-14648) 刺激阶段给药时可阻断终末脂肪生成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CC-410 相关抗体:

Cell Viability Assay[1]

Cell Line: 3T3-L1 mouse embryonic fibroblast pre-adipocytes
Concentration: 1, 5, 10, 25 μM
Incubation Time: different conditions: every 48 h throughout the differentiation period; once in the first 20 h following DIM stimulation; once 48 h after DIM stimulation; or after the early differentiation phase
Result: Showed minimal cytotoxicity across all tested concentrations and schedules.
Induced only a slight reduction in cell viability relative to untreated controls at the highest concentration of 25 μM.
分子量

462.67

Formula

C27H46N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CC-410 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CC-410636564-27-7CC410CC 410Amine N-methyltransferasemouse NNMThuman NNMTC3H10T1/2 mouse embryonic stem cell precursor cellsNNMTHEK293 cellsSET1b ComplexPRMT33T3-L1 pre-adipocytesNicotinamide N-methyltransferaseSMYD2Inhibitorinhibitorinhibit

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目录号：
HY-186163
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