2. Metabolic Enzyme/Protease Stem Cell/Wnt JAK/STAT Signaling
  3. Glycosidase STAT
  4. CHI3L1-IN-7

CHI3L1-IN-7 是一种选择性 CHI3L1 抑制剂，其 Kd 为 7.40 μM，IC50 为 15.4 μM。CHI3L1-IN-7 可阻断 CHI3L1 与半乳糖凝集素-3 的相互作用，抑制 STAT3 磷酸化，降低多细胞 3D 胶质母细胞瘤球状体的活力。CHI3L1-IN-7 可用于胶质母细胞瘤及 CHI3L1 介导的肿瘤免疫调控相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CHI3L1-IN-7

CHI3L1-IN-7 Chemical Structure

CAS No. : 2248987-74-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CHI3L1-IN-7 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHI3L1-IN-7 is a selective CHI3L1 inhibitor with a Kd of 7.40 μM and an IC50 of 15.4 μM. CHI3L1-IN-7 blocks CHI3L1's interaction with galectin-3, inhibits STAT3 phosphorylation, reduces the viability of multicellular 3D glioblastoma spheroids. CHI3L1-IN-7 can be used for the research of glioblastoma and CHI3L1-mediated tumor immune regulation[1].

IC50 & Target

STAT3

 

体外研究
(In Vitro)

CHI3L1-IN-7 (100 μM) 可与 CHI3L1 蛋白结合，Kd = 7.40 μM[1]。
CHI3L1-IN-7 可在 AlphaLISA 实验中抑制 CHI3L1 与半乳糖凝集素-3 的相互作用，IC50 = 15.4 μM[1]。
CHI3L1-IN-7 (10-50 μM; 72 h) 可降低多细胞 3D 胶质母细胞瘤 (GBM) 球状体的活力，并抑制 STAT3 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHI3L1-IN-7 相关抗体:

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[1]

Cell Line: multicellular 3D glioblastoma (GBM) spheroids
Concentration: 10, 25, 50 μM
Incubation Time: 72 h
Result: Reduced the viability of multicellular 3D glioblastoma (GBM) spheroids.
分子量

357.43

Formula

C17H19N5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CHI3L1-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHI3L1-IN-72248987-74-6GlycosidaseSTATgalectin-3STAT3CHI3L1glioblastoma spheroidsglioblastomaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CHI3L1-IN-7
目录号：
HY-181783
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z