2. Others Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Drug Derivative Apoptosis Caspase PARP
  4. CHNQD-00824

CHNQD-00824 是一种 Terphenyllin (HY-119821) 衍生物，具有强效抗癌作用。CHNQD-00824 通过诱导 DNA 损伤来抑制癌细胞的增殖和迁移，并能触发细胞凋亡 (apoptosis)。CHNQD-00824 抑制 Doxycin Hydrochloride (DOX) 诱导的斑马鱼胚胎肝脏特异性肿大。CHNQD-00824 适用于肝癌和乳腺癌等癌症研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CHNQD-00824

CHNQD-00824 Chemical Structure

CAS No. : 2222643-74-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥8330
1 - 2 周
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

CHNQD-00824 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHNQD-00824 is a Terphenyllin (HY-119821) derivative with potent anticancer effect. CHNQD-00824 inhibits the proliferation and migration of cancer cells via DNA damage. CHNQD-00824 triggers apoptosis and inhibits Doxycin Hydrochloride (DOX)-induced liver-specific enlargement in zebrafish embryos. CHNQD-00824 can be used for cancer research, such as liver and breast cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.25 μM
Compound: 29
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 29407953]
HeLa IC50
0.15 μM
Compound: 29
Cytotoxicity against human HeLa cells by SRB assay
Cytotoxicity against human HeLa cells by SRB assay
[PMID: 29407953]
HepG2 IC50
0.43 μM
Compound: 29
Cytotoxicity against human HepG2 cells by SRB assay
Cytotoxicity against human HepG2 cells by SRB assay
[PMID: 29407953]
体外研究
(In Vitro)

CHNQD-00824 (72 小时) 对一系列癌细胞表现出强效抑制活性，包括 RCC4、HeLa、Hep G2、U2OS、U251、DU145、TE-1、BT549、HCT8 和 MCF7 细胞，其 IC50 值分别为 2.65、0.45、7.64、 0.44、5.43、0.91、4.35、0.16、0.61 和 3.66 μM[1]。
CHNQD-00824 (0-8 μM，7-13 天) 能剂量依赖性地抑制 BT549 细胞的集落形成[1]。
CHNQD-00824 (0-10 μM，0-24 小时) 能以时间和浓度依赖的方式抑制 BT549 细胞的迁移[1]。
CHNQD-00824 (0-8 μM，24 小时) 可在 BT549 细胞中诱导 G2 期细胞周期阻滞，并通过 DNA 损伤以浓度和 caspase 依赖的方式诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHNQD-00824 相关抗体:

Cell Cycle Analysis[1]

Cell Line: BT549 cells
Concentration: 0, 0.25, 0.5, and 1 μM
Incubation Time: 24 h
Result: Decreased percentage of cells in the G2 phase in a dose-dependent manner from 31.78% to 10.44%.

Cell Migration Assay [1]

Cell Line: BT549 cells
Concentration: 0, 1, 5, and 10 μM
Incubation Time: 0, 12, and 24 h
Result: Showed no significant effect on the cell viability after 12 h treatment.
Significantly inhibited cell migration at concentrations of 5 and 10 μM.
Exhibited a notable inhibitory effect on cell migration after 24 h at concentrations of 1, 5, and 10 μM.

Cell Proliferation Assay[1]

Cell Line: BT549 cells
Concentration: 0, 2, 4, 5, and 8 μM
Incubation Time: 7, and 13 days
Result: Dose-dependently reduced the formation of colonies after 13 days.
Almost completely inhibited cell proliferation at a concentration of 5 μM after 7 days.

Apoptosis Analysis[1]

Cell Line: BT549 cells
Concentration: 0, 0.25, 0.5, and 1 μM
Incubation Time: 0, 12, and 24 h
Result: Resulted in a dose-dependent increase in the percentage of apoptotic cells (0.25, 0.5, and 1 μM), reaching 10.66%, 14.67%, and 23.50%, respectively.
Significantly induced apoptosis in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: BT549 cells
Concentration: 0, 0.5, 2, and 8 μM
Incubation Time: 24 h
Result: Led to an increase in the levels of cleaved-PARP1 (C-PARP1) and Cytochrome C (Cyto C) at 0.5, 2, and 8 μM.
Increased the level of cleaved-caspase 3 (C-Cas3) at the concentrations of 2 and 8 μM.
Increased the pre-apoptotic protein BAD at the concentrations of 8 μM.
Increased γH2AX levels in a concentration-dependent manner.
体内研究
(In Vivo)

CHNQD-00824 (0-15 μM，从受精后 24 小时至 48 小时) 通过 DNA 损伤导致斑马鱼细胞死亡[1]。
CHNQD-00824 (1.25-5 μM，从受精后第 3 天至第 7 天) 以剂量依赖的方式抑制斑马鱼胚胎中由 DOX 诱导的肝脏特异性肿大[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

418.48

Formula

C26H26O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CHNQD-00824 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHNQD-008242222643-74-3CHNQD00824CHNQD 00824Drug DerivativeApoptosisCaspasePARPDrug derivativepoly ADP ribose polymeraseTerphenyllinDNA damageliver-specific enlargementzebrafish embryosliver cancerbreast cancerBT549 cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CHNQD-00824
目录号：
HY-177869
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z