2. Metabolic Enzyme/Protease
  3. 17β-HSD
  4. CRT0083914

CRT0083914 (compound 12) 是 AKR1C3 的亚型选择性非羧酸盐类抑制剂。CRT0083914 可用于结肠癌的研究。

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CRT0083914

CRT0083914 Chemical Structure

CAS No. : 932495-16-4

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CRT0083914 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CRT0083914 (compound 12) is a subtype-selective non-carboxylate inhibitor of AKR1C3. CRT0083914 is applicable to the research of colon cancer[1].

体外研究
(In Vitro)

CRT0083914 (0.1 nM to 100 μM) 可强效且选择性地抑制重组人源 AKR1C3 酶，其 IC50 为 0.094 μM；而在测试浓度下，该化合物对 AKR1C1、AKR1C2、AKR1C4、COX-1 或 COX-2 均无活性[1]。
CRT0083914 可在过表达 AKR1C3 的 HCT-116 细胞中抑制 AKR1C3 依赖性 PR-104A 代谢，其 IC50 为 11 nM[1]。
CRT0083914 以其 2-吡咯烷酮结合 AKR1C3 的 SP3 口袋，以其含磺酰胺的基团结合 SP1 口袋，与该酶的氧阴离子空穴残基无直接接触[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CRT0083914 相关抗体:
分子量

322.42

Formula

C16H22N2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CRT0083914 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRT0083914932495-16-4CRT 0083914CRT-008391417β-HSD17beta-HSD17β-hydroxysteroid dehydrogenases17 beta-hydroxysteroid dehydrogenaseAKR1C4AKR1C1COX-1COX-2AKR1C2PR-104AHCT-116 cellsAKR1C3SP3 pocketcolon cancerInhibitorinhibitorinhibit

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