2. Metabolic Enzyme/Protease
  3. Aldose Reductase
  4. CRT0093964

CRT0093964 是一种选择性、非羧酸类 AKR1C3 抑制剂 (IC50=0.11 μM)，对 AKR1C1、AKR1C2、AKR1C4、COX-1 和 COX-2 均无活性。CRT0093964 可用于白血病、激素相关癌症、结肠癌的研究。

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CRT0093964

CRT0093964 Chemical Structure

CAS No. : 700856-05-9

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CRT0093964 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CRT0093964 is an isoform-selective non-carboxylate inhibitor of AKR1C3 (IC50=0.11 μM) with no activity against AKR1C1, AKR1C2, AKR1C4, COX-1, and COX-2.CRT0093964 can be used for the research of leukemia, hormone-related cancers, colon cancer[1].

体外研究
(In Vitro)

CRT0093964 (0.1 nM-100 μM; 1 h) 可强效且选择性地抑制纯化的重组 AKR1C3，其 IC50 为 0.11 μM；而在最高达 30 μM 的浓度下，该化合物对 AKR1C1、AKR1C2 或 AKR1C4 均无抑制作用[1]。
CRT0093964 (1 nM-3 μM; 2 h 预处理) 可在过表达 AKR1C3 的 HCT-116 细胞中抑制 AKR1C3 依赖的 PR-104A (HY-16405) 代谢，其 IC50 为 0.018 μM，在细胞水平实验中的效力高于纯化酶实验[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CRT0093964 相关抗体:
分子量

309.79

Formula

C15H20ClN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CRT0093964 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRT0093964700856-05-9CRT 0093964CRT-0093964Aldose ReductaseAKR1C4AKR1C1COX-1COX-2leukemiaAKR1C2HCT-116 cellsAKR1C3X-ray crystallographycolon cancerInhibitorinhibitorinhibit

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