2. Metabolic Enzyme/Protease Anti-infection
  3. Cytochrome P450 Fungal
  4. CYP51-IN-32

CYP51-IN-32 是一种抗真菌剂，其针对白色念珠菌的 CYP51 的 IC50 为 0.331 μM。CYP51-IN-32 可释放硫化氢 (H2S)，抑制白色念珠菌的菌丝形成与生物膜发育。CYP51-IN-32 可制备为 PEG 类纳米囊泡。CYP51-IN-32 可用于白色念珠菌感染的研究。

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CYP51-IN-32

CYP51-IN-32 Chemical Structure

CAS No. : 205251-67-8

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CYP51-IN-32 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CYP51-IN-32 is an antifungal agent with an IC50 of 0.331 μM against CYP51 of Candida albicans. CYP51-IN-32 releases hydrogen sulfide (H2S) and inhibits hyphal formation and biofilm development of Candida albicans. CYP51-IN-32 can be formulated into PEG-based nanovesicles. CYP51-IN-32 is applicable to the research of Candida albicans infection[1].

IC50 & Target[1]

CYP51

0.331 μM (IC50)

体外研究
(In Vitro)

CYP51-IN-32 (Compound 3j) (聚乙二醇 - 脂质体包裹) 可强效抑制白念珠菌生长，其 MIC 为 4.68 μg/mL[1]。
CYP51-IN-32 对白色念珠菌的抗真菌活性会在 H2S 被 1.5 mg/mL MgO 清除时降低，其 MIC 升至 32 μg/mL[1]。
CYP51-IN-32 可强效抑制白色念珠菌的菌丝形成，使该真菌维持在单细胞酵母形态[1]。
CYP51-IN-32 可在 0.0005 mg/mL 浓度下将白色念珠菌的生物膜形成抑制 60%[1]。
CYP51-IN-32 对 WS-1 人皮肤成纤维细胞的 IC50 为 65.73 μg/mL，相对于其抗白色念珠菌的抗真菌 MIC，其选择性指数约为 14.0[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CYP51-IN-32 相关抗体:
分子量

390.95

Formula

C19H19ClN2OS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CYP51-IN-32 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

CYP51-IN-32205251-67-8Cytochrome P450FungalCYPshydrogen sulfideCandida albicans infectionWS-1 human skin fibroblastshyphal formationbiofilm developmentlanosterol 14α-demethylasemammalian fibroblastsPEG-niosomesCYP51Candida albicansInhibitorinhibitorinhibit

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