2. Anti-infection
  3. Bacterial
  4. Ditophal

Ditophal 是一种口服有效的硫醇酯类抗结核及抗麻风病剂。Ditophal 可对抗豚鼠体内皮下及脑内的结核分枝杆菌感染，包括耐 Isoniazid (HY-B0329) 菌株。Ditophal 可改变麻风分枝杆菌的染色特性，降低麻风病细菌指数。Ditophal 以高剂量对豚鼠皮下给药时，会导致注射部位溃疡。Ditophal 可用于结核病和麻风病的研究。

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Ditophal

Ditophal Chemical Structure

CAS No. : 584-69-0

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Ditophal 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ditophal is an orally active thiol ester anti-tuberculosis and anti-leprosy agent. Ditophal combats Mycobacterium tuberculosis infections in subcutaneous and intracerebral sites in guinea pigs, including isoniazid (HY-B0329)-resistant strains. Ditophal alters the staining characteristics of Mycobacterium leprae and reduces the bacterial index of leprosy. Ditophal causes ulcers at the injection site when administered subcutaneously to guinea pigs at high doses. Ditophal can be used in the research of tuberculosis and leprosy[1][2].

体内研究
(In Vivo)

Ditophal (100-200 mg/kg；口服；每日 2 次；共 90 天) 可降低经皮下感染结核分枝杆菌的豚鼠的结核病器官严重程度评分并延长其存活时间[1]。
Ditophal (10-50 mg/kg；皮下注射；每日或每周；共 120 天) 可降低经皮下感染结核分枝杆菌的豚鼠的结核病器官严重程度评分并延长其存活时间[1]。
Ditophal (100-200 mg/kg；口服；每日 2 次；连续 4 周) 可延长脑内感染结核分枝杆菌的豚鼠的平均存活时间，其中 100 mg/kg 剂量组的平均存活时间更长，达 35.0 天[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Guinea-pigs (434 to 648 g weight; subcutaneous Mycobacterium tuberculosis infection)[1]
Dosage: 200 mg/kg; 100 mg/kg
Administration: p.o.; two doses daily; until 90th day after infection (no treatment on Saturdays or Sundays)
Result: Produced mean total tuberculosis organ score of 7.7 (lung 1.3, liver 0, spleen 2.0, bronchial lymph nodes 4.3) and mean survival time of 99.7 days when started on infection day at 200 mg/kg.
Produced mean total tuberculosis organ score of 9.0 (lung 2.3, liver 1.3, spleen 1.3, bronchial lymph nodes 4.0) and mean survival time of 120 days when started 14 days post-infection at 200 mg/kg.
Produced mean total tuberculosis organ score of 11.3 (lung 2.3, liver 1.3, spleen 2.7, bronchial lymph nodes 5.0) and mean survival time of 81.3 days when started on infection day at 100 mg/kg.
Produced mean total tuberculosis organ score of 9.0 (lung 1.0, liver 0.5, spleen 2.5, bronchial lymph nodes 5.0) and mean survival time of 97.0 days when started 14 days post-infection at 100 mg/kg.
Animal Model: Guinea-pigs (440 to 630 g weight; subcutaneous Mycobacterium tuberculosis infection)[1]
Dosage: 50 mg/kg; 10 mg/kg
Administration: s.c.; once daily or once weekly; until 120th day after infection
Result: Produced mean total tuberculosis organ score of 14.0 (lung 1.7, liver 3.4, spleen 4.3, bronchial lymph nodes 4.6) and mean survival time of 118 days at 50 mg/kg once daily.
Produced mean total tuberculosis organ score of 16.2 (lung 3.9, liver 4.25, spleen 3.8, bronchial lymph nodes 4.4) and mean survival time of 88.6 days at 50 mg/kg once weekly.
Produced mean total tuberculosis organ score of 15.25 (lung 3.9, liver 3.75, spleen 3.5, bronchial lymph nodes 4.1) and mean survival time of 100 days at 10 mg/kg once daily.
Produced mean total tuberculosis organ score of 13.6 (lung 4.1, liver 2.5, spleen 2.75, bronchial lymph nodes 4.25) and mean survival time of 100 days at 10 mg/kg once weekly.
Animal Model: Guinea-pigs (238 to 472 g weight; intracerebral Mycobacterium tuberculosis infection)[1]
Dosage: 200 mg/kg; 100 mg/kg
Administration: p.o.; two doses daily; 4 weeks (started day after infection)
Result: Produced mean survival time of 28.5 days at 200 mg/kg.
Produced mean survival time of 35.0 days at 100 mg/kg.
分子量

254.36

Formula

C12H14O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ditophal 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ditophal584-69-0EtisulBacterialMycobacterium tuberculosisisoniazid-resistant strainsleprosytuberculosisMycobacterium lepraeDDSleprosy bacterial indexguinea-pigsInhibitorinhibitorinhibit

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