2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel MAPK/ERK Pathway Stem Cell/Wnt Apoptosis
  3. Reactive Oxygen Species (ROS) Calcium Channel JNK ERK p38 MAPK Apoptosis
  4. Evariquinone

Evariquinone 是一种蒽醌类化合物，可从桑树内生真菌 Colletotrichumsp. JS-0367 中发现。Evariquinone 具有直接抗氧化活性，可通过抑制 ROS 和 Ca²⁺，进而抑制 JNK、ERK1/2 和 p38 MAPK 信号通路的过度磷酸化，最终减轻神经元凋亡 (apoptosis)。Evariquinone 可用于研究谷氨酸兴奋毒性相关的神经系统疾病 (如阿尔茨海默病、帕金森病、脑缺血等)。

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Evariquinone

Evariquinone Chemical Structure

CAS No. : 594860-23-8

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Evariquinone 相关抗体

Top Publications Citing Use of Products

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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JNK1 JNK2 JNK3 JNK

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ERK ERK1 ERK2 ERK5 ERK8

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Evariquinone is an anthraquinone compound isolated from the endophytic fungus Colletotrichum sp. JS-0367 of mulberry. Evariquinone possesses direct antioxidant activity. It inhibits excessive phosphorylation of the JNK, ERK1/2 and p38 MAPK signaling pathways by suppressing ROS and Ca2+, thereby reducing neuronal apoptosis. Evariquinone can be used to study glutamate excitotoxicity-related neurological disorders (such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, etc.)[1].

IC50 & Target[1]

ERK1

 

ERK2

 

体外研究
(In Vitro)

Evariquinone (10-100 μM) 呈现出浓度依赖性的 DPPH 自由基清除活性，其 IC50 为 42.2 μM，在 100 μM 时的最大活性为 70%[1]。
Evariquinone (12-100 μM; 24 h) 可在 HT22 细胞中对 5 mM 谷氨酸诱导的细胞毒性产生浓度依赖性神经保护作用，在 50 μM 和 100 μM 浓度下可将细胞活力恢复至接近对照组水平[1]。
Evariquinone (50-100 μM; 8 h) 可显著抑制 HT22 细胞中由 5 mM 谷氨酸诱导的细胞内 ROS 累积[1]。
Evariquinone (50-100 μM; 8 h) 可显著阻断 HT22 细胞中 5 mM 谷氨酸诱导的细胞内 Ca2+ 内流，在 100 μM 浓度下可将荧光强度降至接近对照组水平[1]。
Evariquinone (50-100 μM; 8 h) 可显著抑制 HT22 细胞中 5 mM 谷氨酸诱导的 JNK、ERK1/2 和 p38 磷酸化[1]。
Evariquinone (50-100 μM; 10 h) 可显著减弱 5 mM 谷氨酸诱导的 HT22 细胞凋亡性死亡，分别将凋亡细胞比例降至约 18%和 14%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Evariquinone 相关抗体:

Cell Viability Assay[1]

Cell Line: immortalized murine hippocampal HT22 neuronal cells
Concentration: 12-100 μM
Incubation Time: 24 h
Result: Significantly increased cell viability in a concentration-dependent manner; 12 μM increased cell viability to ~50%, 25 μM to ~80%, 50 μM to ~100%, and 100 μM to ~100% relative to control cells.

Western Blot Analysis[1]

Cell Line: HT22 cells
Concentration: 50, 100 μM
Incubation Time: 8 h
Result: Significantly reduced glutamate-induced phosphorylation of JNK, ERK1/2, and p38; quantitative analysis showed marked decreases in phosphorylated protein levels relative to the glutamate-only treated group.

Apoptosis Analysis[1]

Cell Line: HT22 cells
Concentration: 50, 100 μM
Incubation Time: 10 h
Result: Significantly reduced the percentage of annexin V-positive apoptotic cells; glutamate treatment increased apoptotic cells to ~60%, while 50 μM reduced this to ~18% and 100 μM to ~14%.
分子量

300.26

Formula

C16H12O6
CAS 号
结构分类
初始来源

endosymbiotic Emericella variecolor CLB38
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Evariquinone 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Evariquinone594860-23-8Reactive Oxygen Species (ROS)Calcium ChannelJNKERKp38 MAPKApoptosisCa2+ channelsCa channelsc-Jun N-terminal kinaseExtracellular signal regulated kinasesmitogen-activated protein kinasereactive oxygen speciescalcium ionparkinson’s diseaseextracellular signal-regulated kinase 1/2HT22 cellsapoptotic cell deathalzheimer’s diseasep38 mitogen-activated protein kinaseInhibitorinhibitorinhibit

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