2. Academic Validation
  3. Neuroprotective Compound from an Endophytic Fungus, Colletotrichum sp. JS-0367

Neuroprotective Compound from an Endophytic Fungus, Colletotrichum sp. JS-0367

  • J Nat Prod. 2018 Jun 22;81(6):1411-1416. doi: 10.1021/acs.jnatprod.8b00033.
Ji Hoon Song 1,  Changyeol Lee 2,  Dahae Lee 3,  Soonok Kim 4,  Sunghee Bang 2,  Myoung-Sook Shin 3,  Jun Lee 5 6,  Ki Sung Kang 3,  Sang Hee Shim 2
Affiliations

Affiliations

  • 1 Department of Medicine , University of Ulsan College of Medicine , Seoul 05505 , South Korea.
  • 2 College of Pharmacy , Duksung Women's University , Seoul 01369 , South Korea.
  • 3 College of Korean Medicine , Gachon University , Seongnam 13120 , South Korea.
  • 4 National Institute of Biological Resources , Incheon 22689 , South Korea.
  • 5 Herbal Medicine Research Division , Korea Institute of Oriental Medicine , Daejeon 34054 , Republic of Korea.
  • 6 Convergence Research Center for Diagnosis, Treatment and Care System of Dementia , Korea Institute of Science and Technology , Seoul 02792 , South Korea.
PMID: 29790746 DOI: 10.1021/acs.jnatprod.8b00033
Abstract

Colletotrichum sp. JS-0367 was isolated from Morus alba (mulberry), identified, and cultured on a large scale for chemical investigation. One new anthraquinone (1) and three known Anthraquinones (2-4) were isolated and identified using spectroscopic methods including 1D/2D-NMR and HRESIMS. Although the neuroprotective effects of some Anthraquinones have been reported, the biological activities of the four Anthraquinones isolated in this study have not been reported. Therefore, the neuroprotective effects of these compounds were determined against murine hippocampal HT22 cell death induced by glutamate. Compound 4, evariquinone, showed strong protective effects against HT22 cell death induced by glutamate by the inhibition of intracellular ROS accumulation and CA2+ influx triggered by glutamate. Immunoblot analysis revealed that compound 4 reduced the phosphorylation of MAPKs (JNK, ERK1/2, and p38) induced by glutamate. Furthermore, compound 4 strongly attenuated glutamate-mediated apoptotic cell death.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z