2. Immunology/Inflammation
  3. Interleukin Related
  4. F8-IL-4

F8-IL-4 是一种靶向 IL-4 的免疫细胞因子。F8-IL-4 通过新生血管表达的靶点结合，将 IL-4 特异性递送至炎症部位。F8-IL-4 可通过调控 T 细胞亚群和巨噬细胞极化减轻小鼠的胶原诱导性关节炎。F8-IL-4 与 Dexamethasone (HY-14648) 联用时，可产生协同且持久的治疗效果，通过维持抗炎细胞表型和细胞因子谱来防止停药后关节炎复发。F8-IL-4 可用于胶原诱导性关节炎的研究。

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F8-IL-4

F8-IL-4 Chemical Structure

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F8-IL-4 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

F8-IL-4 is an immune cytokine targeting IL-4. F8-IL-4 specifically delivers IL-4 to inflammatory sites via binding to targets expressed on neovascular vessels. F8-IL-4 alleviates collagen-induced arthritis in mice by regulating T cell subsets and macrophage polarization. When combined with Dexamethasone (HY-14648), F8-IL-4 produces a synergistic and long-lasting therapeutic effect, and prevents arthritis recurrence after drug withdrawal by maintaining anti-inflammatory cell phenotypes and cytokine profiles. F8-IL-4 can be used in the research of collagen-induced arthritis[1].

反应种属

Human
IC50 & Target

IL-4

 

体内研究
(In Vivo)

F8-IL-4 (100 μg per mouse; intraperitoneally; on day 1, 4, and 7 post-disease onset; 10 days) 可通过调控 T 细胞亚群和巨噬细胞极化减轻 DBA/1 小鼠的胶原诱导性关节炎；当与 Dexamethasone (HY-14648) 联用时，可产生协同且持久的治疗效果，通过维持抗炎细胞表型和细胞因子谱来防止停药后关节炎复发[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DBA/1 (10- to 12-week-old male; collagen-induced arthritis model)[1]
Dosage: 100 μg per mouse
Administration: intraperitoneally; on day 1, 4, and 7 post-disease onset; 10 days
Result: Reduced arthritis scores, increased IL-4 levels in joints and serum, decreased IL-1β, IL-17A, IL-6, and GM-CSF levels in the claws, and increased TNF-α levels in the claws.
Significantly increased the total number and percentage of IL-4-secreting T_H2 cells in the joints and significantly decreased the number of IL-17A-secreting CD4+ and TCRγδ T cells.
Increased the percentage of CD206+ macrophages in the claws and decreased the percentage of macrophages expressing MHC class II molecules in the claws.
Decreased the expression of Il12b (p40) mRNA in the spleen.
Produced a synergistic therapeutic effect when used in combination with dexamethasone.
Significantly increased serum IL-10 levels when used in combination with dexamethasone.
When used in combination with dexamethasone:
Significantly decreased the levels of IL-1β, IL-6, GM-CSF, and IL-12p70 in the claws.
Significantly increased the proportion of CD25+FoxP3+ Treg cells among CD4+ T cells in the joints and significantly decreased the T_H17/Treg cell ratio.
Significantly increased the percentage of CD206+ macrophages in the claws and significantly decreased the percentage of total macrophages and macrophages highly expressing MHC class II molecules in the claws.
Significantly increased the expression of arginase 1, IL-10, and Chil3 (Ym1) mRNA in the spleen and significantly decreased the expression of Nos2 and Il12b (p40) mRNA.
Significantly decreased the total number of cells, T_H17 cells, IL-17A+ TCRγδ T cells, and neutrophils in the claws.
Significantly decreased the levels of IL-17A, IL-1β, and IL-12 in the claws and significantly increased the serum IL-10 level.
Significantly increased the percentage of CD206+ macrophages in the claws and decreased the percentage of MHC class II positive macrophages.
Significantly increased the expression of arginase 1 and IL-10 mRNA in the spleen, and decreased the expression of IL-12b (p40) mRNA.
基因 ID

2335  [NCBI]

Accession
靶点

Fibronectin
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

F8-IL-4 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

F8-IL-4Interleukin RelatedILimmune cytokinecollagen-induced arthritisDBA/1 miceInhibitorinhibitorinhibit

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