2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis PI3K/Akt/mTOR
  3. Fatty Acid Synthase (FASN) Reactive Oxygen Species (ROS) Apoptosis PI3K Akt Caspase
  4. FASN-IN-8

FASN-IN-8 是一种脂肪酸合酶 (FASN) 抑制剂。FASN-IN-8 可抑制 FASN 介导的从头脂肪生成。FASN-IN-8 可阻断 PI3K/AKT 通路的激活，抑制癌细胞的增殖、迁移与侵袭。FASN-IN-8 可诱导细胞凋亡 (apoptosis) 和活性氧 (ROS) 的产生。FASN-IN-8 可促进细胞凋亡。FASN-IN-8 可抑制癌细胞的迁移与侵袭。FASN-IN-8 可用于肝细胞癌的研究。

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FASN-IN-8

FASN-IN-8 Chemical Structure

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FASN-IN-8 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FASN-IN-8 is a fatty acid synthase (FASN) inhibitor. FASN-IN-8 inhibits FASN-mediated de novo lipogenesis. FASN-IN-8 blocks PI3K/AKT pathway activation, inhibits cancer cells proliferation, migration and invasion. FASN-IN-8 induces apoptosis and ROS production. FASN-IN-8 promotes apoptosis.FASN-IN-8 inhibits cancer cell migration and invasion. FASN-IN-8 can be used for the research of hepatocellular carcinoma[1].

IC50 & Target[1]

Caspase 3

 

Caspase 9

 

体外研究
(In Vitro)

FASN-IN-8 (Compound 4) (48 h) 可强效抑制 Hep-G2 肝癌细胞的增殖，其 IC50 为 0.47 μM；对 Huh-7 细胞的活性较低，其 IC50 为 1.43 μM，且相对于正常 HUVEC 细胞具有高度的癌细胞选择性，选择指数为 260[1]。
FASN-IN-8 (0.094-2.35 μM; 24 h) 以浓度依赖的方式抑制 Hep-G2 细胞的集落形成[1]。
FASN-IN-8 (0.094-2.35 μM; 24 h) 可剂量依赖性地抑制 Hep-G2 细胞中的 FASN 活性[1]。
FASN-IN-8 (0.094-2.35 μM; 48 h) 以浓度依赖的方式诱导 Hep-G2 细胞发生半胱天冬酶介导的细胞凋亡；其活化型半胱天冬酶-3 (cleaved-caspase-3) 和活化型半胱天冬酶-9 (cleaved-caspase-9) 的表达水平上调[1]。
FASN-IN-8 (0.094-2.35 μM; 48 h) 可在体外以浓度依赖的方式抑制 Hep-G2 细胞中的 PI3K/AKT 信号通路[1]。
FASN-IN-8 (0.094-2.35 μM; 3 h) 可在 0.094、0.47 和 2.35 μM 浓度下诱导 Hep-G2 细胞呈剂量依赖性产生活性氧[1]。
FASN-IN-8 (0.094-2.35 μM; 48 h) 可呈剂量依赖性地抑制 Hep-G2 细胞的迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FASN-IN-8 相关抗体:

Apoptosis Analysis[1]

Cell Line: human Hep-G2 hepatocellular carcinoma cells
Concentration: 0.094 μM, 0.47 μM, 2.35 μM
Incubation Time: 48 h (flow cytometry; Western blot)
Result: Significantly increased the proportion of apoptotic Hep-G2 cells in a concentration-dependent manner.
Upregulated expression of cleaved-caspase-3 and cleaved-caspase-9 in a concentration-dependent manner, indicating activation of caspase-dependent apoptotic pathways.

Western Blot Analysis[1]

Cell Line: human Hep-G2 hepatocellular carcinoma cells
Concentration: 0.094 μM, 0.47 μM, 2.35 μM
Incubation Time: 48 h
Result: Induced dose-dependent reductions in p-PI3K and p-AKT expression.
Caused significant decreases observed at 0.47 μM and 2.35 μM compared to control.
分子量

1038.10

Formula

C55H63N3O17
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FASN-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FASN-IN-8Fatty Acid Synthase (FASN)Reactive Oxygen Species (ROS)ApoptosisPI3KAktCaspasePhosphoinositide 3-kinasePKBProtein kinase BHep-G2 cellsPI3K/AKT pathwayapoptosisfatty acid synthasehepatocellular carcinomaHUVECsHuh-7 cellsde novo lipogenesisreactive oxygen speciesFASNInhibitorinhibitorinhibit

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