2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB Cell Cycle/DNA Damage
  3. Mitochondrial Metabolism Apoptosis Reactive Oxygen Species (ROS) DNA/RNA Synthesis
  4. FBP

FBP 是一种线粒体靶向的、选择性的抗癌剂。FBP 诱导氧化应激和线粒体 (Mitochondrial) 功能障碍，导致细胞凋亡 (Apoptosis)。FBP 可产生 ROS，并造成癌细胞 DNA 双链断裂。FBP 对癌细胞表现出细胞毒性功效，其中宫颈癌细胞最为敏感。FBP 可用于宫颈癌、肺癌、黑色素瘤、乳腺癌的研究。

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FBP

FBP Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

FBP 相关抗体

Top Publications Citing Use of Products

查看 DNA/RNA Synthesis 亚型特异性产品:

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FBP is a mitochondria-targeted, selective anticancer agent. FBP induces oxidative stress and mitochondrial dysfunction, leading to Apoptosis. FBP generates ROS and causes double-strand DNA breaks in cancer cells. FBP exhibits cytotoxic efficacy against cancer cells, with cervical cancer cells being the most sensitive. FBP can be used for the research of cervical cancer, lung cancer, melanoma and breast cancer[1].

体外研究
(In Vitro)

FBP (50-500 μg/mL; 24 h) 与 NIH3/T3 小鼠胚胎成纤维细胞和 L929 小鼠成纤维细胞具有良好的生物相容性[1]。
FBP (50-500 μg/mL; 24 h) 对多种癌细胞系表现出选择性的浓度依赖性细胞毒性，对 HeLa 宫颈癌细胞的活性最强[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FBP 相关抗体:

Cell Viability Assay[1]

Cell Line: NIH3/T3 mouse embryonic fibroblasts, L929 mouse fibroblasts
Concentration: 50-500 μg/mL
Incubation Time: 24 h
Result: Maintained cell viability above 80% at concentrations up to 200 μg/mL in both cell lines.
Reached an IC50 greater than 220 μg/mL for L929 cells.
Reached an IC50 greater than 290 μg/mL for NIH3/T3 cells.

Cell Cytotoxicity Assay[1]

Cell Line: HeLa human cervical carcinoma cells, A549 human lung adenocarcinoma cells, B16F10 mouse melanoma cells, 4T1 murine mammary carcinoma cells
Concentration: 50-500 μg/mL
Incubation Time: 24 h
Result: Induced concentration-dependent reductions in cell viability across all tested cancer cell lines.
Showed the highest sensitivity against HeLa cells, with an IC50 of 180 μg/mL and a selectivity index of 1.61 relative to NIH3/T3 cells.
Reached an IC50 of 290 μg/mL and a selectivity index of 1 against A549 cells.
Reached an IC50 of 240 μg/mL and a selectivity index of 1.20 relative to NIH3/T3 cells against B16F10 and 4T1 cells.
分子量

535.20

Formula

C24H22FeIN3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FBP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FBPMitochondrial MetabolismApoptosisReactive Oxygen Species (ROS)DNA/RNA SynthesisNIH3/T3 mouse embryonic fibroblastsreactive oxygen speciesHeLa human cervical carcinoma cellsapoptotic cell deathsinglet oxygenA549 human lung adenocarcinoma cellsB16F10 mouse melanomaDNA double-strand breaksL929 mouse fibroblastsmitochondriaInhibitorinhibitorinhibit

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目录号：
HY-182266
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