2. 天然产物
  3. 植物 生物碱
  4. 腊梅科 其他类生物碱
  5. 腊梅
  6. (-)-Folicanthine

(-)-Folicanthine 是一种被发现存在于蜡梅 (Chimonanthus praecox) 果实中的二聚色胺类生物碱。(-)-Folicanthine 对癌细胞表现出细胞毒性。(-)-Folicanthine 可用于癌症相关研究，例如胃癌和肝癌研究。

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(-)-Folicanthine

(-)-Folicanthine Chemical Structure

CAS No. : 6879-55-6

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(-)-Folicanthine 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

(-)-Folicanthine is a dimeric tryptamine-related alkaloid found in the fruits of Chimonanthus praecox. (-)-Folicanthine shows cytotoxic against cancer cells. (-)-Folicanthine can be used for the research of cancer, such as gastric carcinoma and hepatocarcinoma[1].

体外研究
(In Vitro)

(-)-Folicanthine (Compound 12) (72 h) 对人胃癌 NUGC3 细胞、人肝癌 SNU739 细胞和人神经母细胞瘤 SHSY-5Y 细胞表现出细胞毒活性，其 IC50 值分别为 13.3 ± 1.5 μM、17.0 ± 2.8 μM 和 60.1 ± 3.5 μM，而对人乳腺癌 MCF-7 细胞无显著细胞毒活性 (IC50 >100 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Folicanthine 相关抗体:

Cell Viability Assay[1]

Cell Line: human gastric carcinoma NUGC3 cells, human hepatocarcinoma SNU739 cells, human neuroblastoma SHSY-5Y cells, human breast cancer MCF-7 cells
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Exhibited cytotoxic activity with an IC50 of 13.3 ± 1.5 μM against NUGC3 cells.
Exhibited cytotoxic activity with an IC50 of 17.0 ± 2.8 μM against SNU739 cells.
Exhibited cytotoxic activity with an IC50 of 60.1 ± 3.5 μM against SHSY-5Y cells.
Showed no significant cytotoxicity against MCF-7 cells with an IC50 >100 μM.
分子量

374.52

Formula

C24H30N4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(-)-Folicanthine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Folicanthine6879-55-6Othershuman gastric carcinoma cellsSNU739 cellsNUGC3 cellshuman neuroblastoma cellshepatocarcinomaSHSY-5Y cellshuman hepatocarcinoma cellshuman breast cancer cellsgastric carcinomaChimonanthus praecoxInhibitorinhibitorinhibit

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