2. 多肽产品
  3. 多肽及其衍生物
  4. 多肽药物递送
  5. 响应肽
  6. GALA-Cys

GALA-Cys 是一种经过化学修饰的 GALA 肽 (HY-P5423)，在保留 GALA 功能同时获得了强大的共价偶联能力。GALA-Cys 会发生由 pH 驱动的可逆二级结构转变，重组为两亲性 α-螺旋，发生自寡聚化，穿透脂质膜形成孔道，破坏脂质双分子层，从而实现内体逃逸和胞质 cargo 递送。GALA-Cys 可与脂质 DPTE 偶联以整合至脂质体中，在金表面自组装为倾斜单分子层，并可用作颗粒表面功能化的 pH 响应型涂层。GALA-Cys 可用于靶向 cargo 递送的相关研究。

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Custom Peptide Synthesis

GALA-Cys

GALA-Cys Chemical Structure

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GALA-Cys 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GALA-Cys is a chemically modified GALA peptide (HY-P5423) that retains GALA functions while acquiring strong covalent conjugation capability. GALA-Cys undergoes pH-driven reversible secondary structure transition, rearranges into an amphipathic α-helix, self-oligomerizes, penetrates lipid membranes to form pores, and disrupts lipid bilayers, thereby enabling endosomal escape and cytosolic cargo delivery. GALA-Cys can be conjugated with lipid DPTE for integration into liposomes, self-assembles into a tilted monolayer on gold surfaces, and serves as a pH-responsive coating for particle surface functionalization. GALA-Cys is applicable to studies related to targeted cargo delivery[1][2].

体外研究
(In Vitro)

GALA-Cys 通过吡啶二硫化物点击化学，与含有巯基的磷脂 DPTE​ 共价连接，生成脂肽 DPTE-GALA。这个脂肽可以像普通磷脂一样，在制备脂质体时定量、可控地掺入到脂质双分子层中[1]。
GALA-Cys 可利用末端的半胱氨酸巯基，直接与金表面形成稳定的 Au-S 共价键，从而在金基底上形成自组装单层膜[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GALA-Cys 相关抗体:
分子量

3176.55

Formula

C141H223N35O46S
Sequence

Ac-Trp-Glu-Ala-Ala-Leu-Ala-Glu-Ala-Leu-Ala-Glu-Ala-Leu-Ala-Glu-His-Leu-Ala-Glu-Ala-Leu-Ala-Glu-Ala-Leu-Glu-Ala-Leu-Ala-Ala-Cys-NH2
Sequence Shortening

Ac-WEAALAEALAEALAEHLAEALAEALEALAAC-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GALA-Cys 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GALA-CysOthersDPTEPOPC liposomeslipid bilayersgold surfacescalceinsaporin toxinmouse embryonic fibroblastsendosomal escapeDPPC vesicle membranescytosolic cargo deliveryInhibitorinhibitorinhibit

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目录号：
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