2. Academic Validation
  3. Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces

Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces

  • Chem Commun (Camb). 2015;51(2):273-275. doi: 10.1039/c4cc07278b.
Joe E Baio # 1,  Denise Schach # 1,  Adrian V Fuchs 1,  Lars Schmüser 1,  Nils Billecke 1,  Christoph Bubeck 1,  Katharina Landfester 1,  Mischa Bonn 1,  Michael Bruns 2,  Clemens K Weiss 1 3,  Tobias Weidner 1
Affiliations

Affiliations

  • 1 Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
  • 2 Karlsruhe Institute of Technology, Institute for Applied Materials and Karlsruhe Nano Micro Facility, 76344 Eggenstein-Leopoldshafen, Germany.
  • 3 University of Applies Sciences Bingen, 55411 Bingen, Germany.
  • # Contributed equally.
PMID: 25329926 DOI: 10.1039/c4cc07278b
Abstract

pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface.

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  • HY-P5423C
    Cys修饰GALA肽
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