2. Others Cell Cycle/DNA Damage Apoptosis MAPK/ERK Pathway
  3. Drug Derivative DNA Alkylator/Crosslinker Topoisomerase Apoptosis JNK
  4. Galarubicin hydrochloride

Galarubicin hydrochloride (DA 125) 是一种新型 Anthracycline 衍生物。Galarubicin hydrochloride 具有高亲和力的 DNA 结合能力和拓扑异构酶 II (topoisomerase II) 抑制活性。Galarubicin hydrochloride 可诱导细胞凋亡 (Apoptosis)。Galarubicin hydrochloride 通过 JNK 通路发挥细胞毒性作用。Galarubicin hydrochloride 可用于肝细胞癌的研究。

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Galarubicin hydrochloride

Galarubicin hydrochloride Chemical Structure

CAS No. : 140637-82-7

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Galarubicin hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II DNA gyrase

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JNK1 JNK2 JNK3 JNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Galarubicin hydrochloride (DA 125) is a novel Anthracycline derivative. Galarubicin hydrochloride shows high-affinity DNA binding and topoisomerase II inhibitory activities. Galarubicin hydrochloride induces Apoptosis. Galarubicin hydrochloride exerts cytotoxicity via JNK pathway. Galarubicin hydrochloride can be used in the research of hepatocellular carcinoma[1].

IC50 & Target[1]

Topoisomerase II

 

分子量

670.03

Formula

C30H33ClFNO13
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Galarubicin hydrochloride 相关分类

  • 摩尔计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galarubicin140637-82-7DA 125DA125DA-125Drug DerivativeDNA Alkylator/CrosslinkerTopoisomeraseApoptosisJNKDrug derivativec-Jun N-terminal kinasehepatocellular carcinomatopoisomerase IIInhibitorinhibitorinhibit

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Galarubicin hydrochloride
目录号：
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