2. Gene
  3. Maob - monoamine oxidase B Gene

Maob - monoamine oxidase B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：单胺氧化酶 B

种属: Mus musculus

同用名: MAO-B; 6330414K01Rik

基因 ID: 109731 | 基因类型: protein coding

关于 Maob

Chromosome X: 16,575,521-16,683,605 reverse strand.GRCm39:CM001013.3

This gene has 4 transcripts (splice variants), 333 orthologues, 9 paralogues and is associated with 4 phenotypes. Biased expression in placenta adult (RPKM 125.6), liver adult (RPKM 44.7) and 11 other tissues.

功能概要

预测该基因编码的蛋白可启动黄素腺嘌呤二核苷酸结合活性；相同的蛋白质结合活性；和伯胺氧化酶活性。预计参与血清素分泌的负调节；神经递质分解代谢过程；和多巴胺代谢过程的正向调节。位于线粒体内膜。以多种结构表达，包括消化系统；心血管系统;中枢神经系统;泌尿生殖系统；和感觉器官。该基因的人类直系同源物与阿尔茨海默病和帕金森病有关。与人 MAOB（单胺氧化酶 B）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable flavin adenine dinucleotide binding activity; identical protein binding activity; and primary amine oxidase activity. Predicted to be involved in negative regulation of serotonin secretion; neurotransmitter catabolic process; and positive regulation of dopamine metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human MAOB (Monoamine Oxidase B). [provided by Alliance of Genome Resources, Apr 2022]

Maob 基因产物(1)

mRNA Protein Name
NM_172778.2 NP_766366.2 amine oxidase [flavin-containing] B

Maob 蛋白结构

YobN

YobN: COG1231 (5 - 450)

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  • 520 a.a.
蛋白主名 其他名称

amine oxidase [flavin-containing] B

monoamine oxidase type B

相关产品

Approval
生物活性分子 (16)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14199 Selegiline hydrochloride Inhibitor 99.96% 否
HY-12723 Apomorphine 99.48% 否
HY-14280 Entacapone Inhibitor 99.97% 是
HY-N0159 Paeonol 99.98% 否
HY-A0091A Pargyline Inhibitor 99.92% 否
HY-A0091 Pargyline hydrochloride Inhibitor 99.91% 否
HY-B1018A Phenelzine sulfate Inhibitor 99.96% 否
HY-70057 Safinamide Inhibitor 99.86% 是
HY-14855B Tedizolid phosphate Inhibitor 99.61% 是
HY-70057A Safinamide mesylate Inhibitor 99.07% 是
HY-N0159R Paeonol (Standard) 99.98% 否
HY-B1558A Bifemelane hydrochloride Inhibitor 99.86% 否
HY-14198 Selegiline Inhibitor / 否
HY-14280R Entacapone (Standard) Inhibitor 99.24% 否
HY-12723R Apomorphine (Standard) / 否
HY-14280A Entacapone sodium salt Inhibitor / 否
Clinical Phase
生物活性分子 (8)
目录号 产品名 作用方式
纯度 Phase
HY-103164A 8-(3-Chlorostyryl)caffeine / Phase 4
HY-N0529 Rosmarinic acid 99.73% Phase 3
HY-129388B Pulrodemstat benzenesulfonate Inhibitor 99.64% Phase 2
HY-112623 Vafidemstat Inhibitor 98.03% Phase 2
HY-10400 Ladostigil hemitartrate Inhibitor 98.90% Phase 2
HY-10399A Ladostigil hydrochloride Inhibitor 99.91% Phase 2
HY-10399 Ladostigil Inhibitor / Phase 2
HY-129388 Pulrodemstat Methylbenzenesulfonate Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (177)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W008566 Norharmane Inhibitor 99.93% 否
HY-N7204 4-Hydroxyderricin 99.79% 否
HY-W015490 1,4-Naphthoquinone Inhibitor 99.97% 否
HY-110130 RN-1 dihydrochloride Inhibitor 99.13% 否
HY-E70074 Monoamine oxidase, plasma / 否
HY-127109 Tisolagiline Inhibitor 99.85% 否
HY-16677A Mofegiline hydrochloride Inhibitor 99.57% 否
HY-N0918 Desmethoxyyangonin 99.46% 否
HY-103164 (E)-8-(3-Chlorostyryl)caffeine 99.4% 否
HY-19333 OG-L002 Inhibitor 99.55% 否
HY-N9540 Methyl citrate Inhibitor 98.0% 否
HY-100588 VU0364770 Agonist 99.94% 否
HY-119532 Nordeprenyl 95.13% 否
HY-114520 TT01001 Inhibitor 99.38% 否
HY-D0004 Azure B Inhibitor 99.87% 否
HY-W655727 (-)-2-Phenylpropylamine Inhibitor 96.14% 否
HY-14201 Lazabemide Inhibitor 99.95% 否
HY-14203 (R)-Safinamide Inhibitor 99.89% 否
HY-117173 (Rac)-Rasagiline Inhibitor ≥97.0% 否
HY-127109A Tisolagiline monomethylsulfate Inhibitor 99.83% 否
HY-131036 MAO-IN-M30 dihydrochloride Inhibitor 98.56% 否
HY-156255 MAO-B-IN-25 Inhibitor 99.11% 否
HY-W001601 Budipine Antagonist 99.41% 否
HY-W015490S 1,4-Naphthoquinone-d6 Inhibitor 99.20% 否
HY-129388A Pulrodemstat Inhibitor 98.86% 否
HY-N2336 Rosmarinic acid racemate Inhibitor 98.01% 否
HY-101578 2614W94 Inhibitor 99.76% 否
HY-120419 PF9601N Inhibitor 99.85% 否
HY-120826 A2AAR/hMAO-B-IN-1 Inhibitor 99.0% 否
HY-121072 ASS234 Inhibitor 99.6% 否
HY-127109B Tisolagiline methylsulfate Inhibitor / 否
HY-132907 MAO-B-IN-2 Inhibitor 99.05% 否
HY-14280S Entacapone-d10 Inhibitor 98.6% 否
HY-146958 MAO-B-IN-8 Inhibitor 98.03% 否
HY-70057S1 Safinamide-d4-1 Inhibitor 98.90% 否
HY-B1018AS Phenelzine-d5 sulfate Inhibitor 99.97% 否
HY-W010130 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone Inhibitor 99.96% 否
HY-W845607 Milacemide Inhibitor 98.04% 否
HY-172451 MC4762 Inhibitor / 否
HY-100679B (R)-Pirlindole mesylate Inhibitor / 否
HY-103477 MAO-B-IN-51 Inhibitor / 否
HY-106972 SL-251131 Inhibitor / 否
HY-114915 PSB-1434 Inhibitor 98.05% 否
HY-115986 MAO-B-IN-5 Inhibitor / 否
HY-115987 MAO-B-IN-6 Inhibitor / 否
HY-116097 PSB-1491 Inhibitor / 否
HY-116765 MAO-B-IN-35 / 否
HY-117502 SL-25.1188 Inhibitor / 否
HY-129388C Pulrodemstat hydrochloride Inhibitor / 否
HY-129479 Almoxatone Inhibitor / 否
HY-130205 Milacemide hydrochloride Inhibitor / 否
HY-134664 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Inhibitor / 否
HY-14202 Lazabemide hydrochloride Inhibitor / 否
HY-143244 Monoamine Oxidase B inhibitor 1 Inhibitor / 否
HY-143245 Monoamine Oxidase B inhibitor 2 Inhibitor / 否
HY-143329 MAO-B-IN-3 Inhibitor / 否
HY-143330 MAO-B-IN-4 Inhibitor / 否
HY-143438 2-PAT Inhibitor / 否
HY-144673 LSD1-IN-12 Inhibitor / 否
HY-144756 LSD1-IN-15 Inhibitor / 否
HY-144757 LSD1-IN-16 Inhibitor / 否
HY-144758 LSD1-IN-17 Inhibitor / 否
HY-144824 Monoamine oxidase/Aromatase-IN-1 Inhibitor / 否
HY-145695 Dual AChE-MAO B-IN-1 Inhibitor / 否
HY-145845 HDAC1/MAO-B-IN-1 Inhibitor / 否
HY-146149 MAO-B-IN-11 Inhibitor / 否
HY-146150 MAO-B-IN-12 Inhibitor / 否
HY-146312 AChE/BChE/MAO-B-IN-1 Inhibitor 99.57% 否
HY-146314 MAO-B-IN-9 Inhibitor 99.70% 否
HY-146347 MAO-B-IN-10 Inhibitor / 否
HY-146677 5-HT6R/MAO-B modulator 1 / 否
HY-146762 MAO-B-IN-7 Inhibitor / 否
HY-147362 MAO-B-IN-14 Inhibitor / 否
HY-147953 MAO-B-IN-13 Inhibitor / 否
HY-149242 MAO-B-IN-20 Inhibitor / 否
HY-149477 IHC3 Inhibitor / 否
HY-149527 MAO-B-IN-23 Inhibitor / 否
HY-149528 MAO-B-IN-24 Inhibitor / 否
HY-149820 MAO-B-IN-22 Inhibitor / 否
HY-149978 LSD1-IN-26 / 否
HY-149984 MAO-B-IN-21 Inhibitor / 否
HY-150563 Neuroinflammatory-IN-2 Inhibitor / 否
HY-151094 FTEAA Inhibitor / 否
HY-151208 MAO-B-IN-16 Inhibitor / 否
HY-151209 MAO-B-IN-15 Inhibitor / 否
HY-151210 MAO-B-IN-17 Inhibitor ≥99.0% 否
HY-151800 MAO-A/B-IN-2 Inhibitor / 否
HY-152109 AChE/MAO-IN-1 Inhibitor / 否
HY-152110 AChE/MAO-IN-2 Inhibitor / 否
HY-152111 AChE/MAO-B-IN-3 Inhibitor / 否
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / 否
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / 否
HY-152114 AChE/BChE/MAO-B-IN-4 Inhibitor / 否
HY-154977 ETAP Inhibitor / 否
HY-155330 PZ-1922 / 否
HY-155330A PZ-1922 free base / 否
HY-156348 MAO-B-IN-26 Inhibitor / 否
HY-157087 AChE/MAO-B-IN-4 Inhibitor / 否
HY-157089 AChE/MAO-B-IN-5 Inhibitor / 否
HY-157517 MAO-B-IN-29 Inhibitor / 否
HY-157934 MAO-IN-4 Inhibitor / 否
HY-157981 AChE-IN-60 Inhibitor / 否
HY-157982 BChE-IN-28 Inhibitor / 否
HY-158092 ChEs/MAOs-IN-2 Inhibitor / 否
HY-158732 MAO-B-IN-33 Inhibitor / 否
HY-159106 MeSeI / 否
HY-160002 MAO-B-IN-27 Inhibitor / 否
HY-161240 MAO-B-IN-30 Inhibitor 98.53% 否
HY-162061 ChEs/MAOs-IN-1 Inhibitor / 否
HY-162303 C175-0062 Inhibitor / 否
HY-162606 MAO-A/B-IN-3 Inhibitor / 否
HY-162760 COMT-IN-1 Inhibitor / 否
HY-163322 MAO-A inhibitor 2 Inhibitor / 否
HY-163380 CA/MAO-B-IN-1 Inhibitor 98.34% 否
HY-163474 MAO-B-IN-32 Inhibitor / 否
HY-163879 hMAO-B-IN-9 Inhibitor / 否
HY-16731 Sembragiline Inhibitor / 否
HY-168138 MAO-B-IN-34 Inhibitor / 否
HY-168590 MAO-B-IN-36 Inhibitor / 否
HY-168728 MAO-B-IN-37 Inhibitor / 否
HY-169156 HDAC6-IN-49 Inhibitor / 否
HY-170487 MAO-B-IN-38 Inhibitor / 否
HY-170798 Monoamine Oxidase B inhibitor 6 Inhibitor / 否
HY-170887 MAO-B-IN-39 / 否
HY-172101 AChE/MAO-B-IN-7 Inhibitor / 否
HY-172460 AChE/BChE/MAO-B-IN-5 Inhibitor / 否
HY-172461 MAO-IN-6 Inhibitor / 否
HY-173138 FCOB02 Ligand / 否
HY-173288 MAO-B-IN-40 Inhibitor / 否
HY-173336 MAO-B-IN-42 Inhibitor / 否
HY-174419 TFSeB / 否
HY-174834 MAO-B-IN-44 Inhibitor / 否
HY-175523 MAO-B-IN-48 Inhibitor / 否
HY-175524 BChE/MAO-B-IN-2 Inhibitor / 否
HY-176245 Illudinine Inhibitor / 否
HY-176254 LSD1-IN-43 Inhibitor / 否
HY-176271 MAO-B-IN-45 / 否
HY-178149 MAO-A/B-IN-5 Inhibitor / 否
HY-178352 MAO-B-IN-49 / 否
HY-178454 Multitarget AD-IN-3 Inhibitor / 否
HY-179126 BChE/MAO-A-IN-1 Inhibitor / 否
HY-179167 K2V-9 Inhibitor / 否
HY-180114 NSS-18 / 否
HY-180842 MAO-B-IN-50 Inhibitor / 否
HY-180843 Aβ/tau aggregation-IN-4 Inhibitor / 否
HY-181141 AChE/MAO-B-IN-8 Inhibitor / 否
HY-181146 MK-7762 Inhibitor / 否
HY-N15470 MAO-B-IN-52 Inhibitor / 否
HY-N15657 Geiparvarin / 否
HY-N1636 1-Methyl-2-nonyl-4(1H)-quinolone Inhibitor / 否
HY-N1638 1-Methyl-2-undecyl-4(1H)-quinolone Inhibitor / 否
HY-RS08022 MAOB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08023 Maob Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08024 Maob Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W008566S Norharmane-13C / 否
HY-W035384 MAO-B ligand-1 Inhibitor / 否
HY-W083026 (E)-CHBO4 Inhibitor 97.04% 否
HY-W083062 hMAO-B-IN-5 Inhibitor 99.66% 否
HY-W205529 RO 16-6491 free base / 否
HY-W269511 NW-1689 / 否
HY-W335927 MAO-B-IN-19 Inhibitor / 否
HY-W628136 MAO-B-IN-47 Inhibitor / 否
HY-10399B (S)-Ladostigil Inhibitor / 否
HY-105041 Tedizolid phosphate sodium Inhibitor / 否
HY-123556 SZV-558 Inhibitor / 否
HY-123665 PSB-1410 Inhibitor 99.22% 否
HY-129444 MD 780236 free base Inhibitor / 否
HY-14198S Selegiline-d5 Inhibitor / 否
HY-14199S Selegiline-d5 hydrochloride Inhibitor / 否
HY-164649 Atibeprone Inhibitor / 否
HY-19333A OG-L002 hydrochloride Inhibitor / 否
HY-70057S4 Safinamide-d5 Inhibitor / 否
HY-N12134 Methyl piperate Inhibitor / 否
HY-N13041 Acacetin 7-O-(6-O-malonylglucoside) Inhibitor / 否
HY-W029600 6,7-Dimethylisatin Inhibitor / 否
HY-W700241 Norharman-d7 Inhibitor / 否
HY-W792513 WAY-620147 Inhibitor 98.0% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Maob NCBI NCBI:4129
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