2. Gene
  3. Abr - active BCR-related gene Gene

Abr - active BCR-related gene Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 109934 | 基因类型: protein coding

关于 Abr

功能概要

Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including neuromuscular process controlling balance; regulation of vesicle-mediated transport; and response to lipopolysaccharide. Located in cytosol; glutamatergic synapse; and plasma membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; mesothelium; metanephros; nervous system; and sensory organ. Orthologous to human ABR (ABR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Abr 基因产物(6)

mRNA Protein Name
NM_001291186.2 NP_001278115.1 active breakpoint cluster region-related protein isoform 4
NM_001346670.2 NP_001333599.1 active breakpoint cluster region-related protein isoform 5
NM_001363379.2 NP_001350308.1 active breakpoint cluster region-related protein isoform 6
NM_198018.3 NP_932135.1 active breakpoint cluster region-related protein isoform 1
NM_198894.3 NP_942597.1 active breakpoint cluster region-related protein isoform 2
NM_198895.3 NP_942598.1 active breakpoint cluster region-related protein isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
17116687 MGI
enables GTPase activator activity IGI
IGI: 通过遗传相互作用推断
19703997 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
17116687 MGI
acts upstream of or within brain development IGI
IGI: 通过遗传相互作用推断
11684658 MGI
acts upstream of cell migration IGI
IGI: 通过遗传相互作用推断
17116687 MGI
acts upstream of establishment of localization in cell IGI
IGI: 通过遗传相互作用推断
17116687 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: 通过遗传相互作用推断
11921339 MGI
acts upstream of macrophage migration IGI
IGI: 通过遗传相互作用推断
17116687 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
20962234 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
20962234 MGI
involved in negative regulation of blood vessel remodeling IMP
IMP: 通过突变表型推断
23152932 MGI
involved in negative regulation of cellular extravasation IMP
IMP: 通过突变表型推断
23152932 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
19703997 MGI
acts upstream of or within negative regulation of macrophage migration IGI
IGI: 通过遗传相互作用推断
17116687 MGI
acts upstream of or within negative regulation of neutrophil degranulation IGI
IGI: 通过遗传相互作用推断
19703997 MGI
acts upstream of or within neuromuscular process controlling balance IGI
IGI: 通过遗传相互作用推断
11921339 MGI
acts upstream of neutrophil degranulation IGI
IGI: 通过遗传相互作用推断
19703997 MGI
acts upstream of phagocytosis IGI
IGI: 通过遗传相互作用推断
17116687 MGI
acts upstream of or within positive regulation of phagocytosis IGI
IGI: 通过遗传相互作用推断
17116687 MGI
involved in regulation of vascular permeability IMP
IMP: 通过突变表型推断
23152932 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: 通过突变表型推断
19703997 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
20962234 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
20962234 MGI
located in cytosol IDA
IDA: 通过直接分析推断
17116687 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
20962234 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
20962234 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
17116687 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

active breakpoint cluster region-related protein

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13010 Laquinimod 99.46% 是
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-10528 Tasquinimod Modulator 99.70% Phase 3
HY-13743 Roquinimex Inhibitor 99.69% Phase 3
HY-100442 Paquinimod Inhibitor 99.90% Phase 2
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-141537 ABR-238901 Inhibitor 98.92% 否
HY-100442S1 Paquinimod-d5-1 Inhibitor 98.19% 否
HY-10528S Tasquinimod-d3 Modulator 99.34% 否
HY-13010S Laquinimod-d5 Inhibitor 98.25% 否
HY-W062904 Laquinimod sodium Inhibitor / 否
HY-RS00110 ABR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-100442S Paquinimod-d5 Inhibitor / 否
HY-RS17572 Abr Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24032 Abr Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99436 Anatumomab mafenatox Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Abr NCBI NCBI:29
Macaca fascicularis Abr NCBI NCBI:102126046
Rattus norvegicus Abr NCBI NCBI:287537
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