2. Gene
  3. ABR - Abr ABR activator of RhoGEF and GTPase Gene

ABR - Abr ABR activator of RhoGEF and GTPase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 287537 | 基因类型: protein coding

关于 ABR

功能概要

Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of blood vessel remodeling; and negative regulation of cellular extravasation. Predicted to act upstream of or within several processes, including neuromuscular process controlling balance; regulation of vesicle-mediated transport; and response to lipopolysaccharide. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human ABR (ABR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]

ABR 基因产物(1)

mRNA Protein Name
NM_001105814.4 NP_001099284.1 active breakpoint cluster region-related protein
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20962234 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
20962234 RGD
is active in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
20962234 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

active breakpoint cluster region-related protein

ABR, RhoGEF and GTPase activating protein

active BCR-related

breakpoint cluster region protein-like

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13010 Laquinimod 99.46% 是
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-10528 Tasquinimod Modulator 99.70% Phase 3
HY-13743 Roquinimex Inhibitor 99.69% Phase 3
HY-100442 Paquinimod Inhibitor 99.90% Phase 2
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-141537 ABR-238901 Inhibitor 98.92% 否
HY-100442S1 Paquinimod-d5-1 Inhibitor 98.19% 否
HY-10528S Tasquinimod-d3 Modulator 99.34% 否
HY-13010S Laquinimod-d5 Inhibitor 98.25% 否
HY-W062904 Laquinimod sodium Inhibitor / 否
HY-RS00110 ABR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-100442S Paquinimod-d5 Inhibitor / 否
HY-RS17572 Abr Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24032 Abr Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99436 Anatumomab mafenatox Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ABR NCBI NCBI:29
Macaca fascicularis ABR NCBI NCBI:102126046
Mus musculus ABR NCBI NCBI:109934
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