2. Gene
  3. Bcl10 - B cell leukemia/lymphoma 10 Gene

Bcl10 - B cell leukemia/lymphoma 10 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CLAP; ME10; cE10; CIPER; BCL-10; CARMEN

基因 ID: 12042 | 基因类型: protein coding

关于 Bcl10

功能概要

Enables CARD domain binding activity and identical protein binding activity. Involved in Antifungal innate immune response; neural tube closure; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; lymphocyte apoptotic process; and regulation of signal transduction. Located in cytosol; immunological synapse; and membrane raft. Part of CBM complex and polkadots. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; sensory organ; and vibrissa follicle. Human ortholog(s) of this gene implicated in MALT lymphoma; immunodeficiency 37; malignant mesothelioma; and non-Hodgkin lymphoma. Orthologous to human BCL10 (BCL10 immune signaling adaptor). [provided by Alliance of Genome Resources, Apr 2022]

Bcl10 基因产物(1)

mRNA Protein Name
NM_009740.2 NP_033870.1 B-cell lymphoma/leukemia 10
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CARD domain binding IPI
IPI: 通过物理相互作用推断
22265677 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16831874 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10187771 MGI
enables signaling adaptor activity IDA
IDA: 通过直接分析推断
35263589 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell apoptotic process IDA
IDA: 通过直接分析推断
10753917 MGI
NOT acts upstream of or within B cell apoptotic process IMP
IMP: 通过突变表型推断
11163238 MGI
acts upstream of or within T cell apoptotic process IDA
IDA: 通过直接分析推断
10753917 MGI
NOT acts upstream of or within T cell apoptotic process IMP
IMP: 通过突变表型推断
11163238 MGI
involved in antifungal innate immune response IDA
IDA: 通过直接分析推断
22265677 MGI
acts upstream of or within cellular defense response IMP
IMP: 通过突变表型推断
11163238 MGI
NOT acts upstream of or within fibroblast apoptotic process IMP
IMP: 通过突变表型推断
11163238 MGI
acts upstream of or within immunoglobulin mediated immune response IMP
IMP: 通过突变表型推断
11163238 MGI
involved in neural tube closure IMP
IMP: 通过突变表型推断
11163238 MGI
involved in non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
11163238 MGI
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
22265677 MGI
acts upstream of or within positive regulation of T cell activation IMP
IMP: 通过突变表型推断
14614861 MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
10753917 MGI
involved in positive regulation of cytokine production IDA
IDA: 通过直接分析推断
22265677 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
10753917 MGI
acts upstream of or within regulation of T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
14614861 MGI
acts upstream of or within response to fungus IMP
IMP: 通过突变表型推断
16862125 MGI
involved in response to lipopolysaccharide IDA
IDA: 通过直接分析推断
35263589 MGI
NOT acts upstream of or within thymocyte apoptotic process IMP
IMP: 通过突变表型推断
11163238 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CBM complex IDA
IDA: 通过直接分析推断
22265677 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
12867038 MGI
located in cytosol IDA
IDA: 通过直接分析推断
16831874 MGI
located in immunological synapse IDA
IDA: 通过直接分析推断
14724296 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
12867038 MGI
part of polkadots IDA
IDA: 通过直接分析推断
16495340 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

B-cell lymphoma/leukemia 10

B-cell CLL/lymphoma 10

CARD-containing molecule enhancing NF-kappa-B

CARD-like apoptotic protein

CED-3/ICH-1 prodomain homologous E10-like regulator

cellular homolog of vCARMEN

cellular-E10

mammalian CARD-containing adapter molecule E10

Bcl10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Bcl10 Q9Z0H7 E10 Equine herpesvirus 2 Q66677
Confocal
11238466
种属间
Bcl10 Q9Z0H7 E10 Equine herpesvirus 2 Q66677
Anti Tag CoIP
11238466
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-142648 MLT-985 Inhibitor 99.49% 否
HY-174371 INNO-220 98.60% 否
HY-131902 MLT-231 Inhibitor 99.55% 否
HY-142648A (R)-MLT-985 Inhibitor / 否
HY-RS01412 BCL10 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17823 Bcl10 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24291 Bcl10 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bcl10 NCBI NCBI:8915
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z