Runx2 - runt related transcription factor 2 Gene

种属: Mus musculus

同用名: Cbf; LS3; AML3; Osf2; Cbfa1; Cbfa-1; PEBP2aA; Pebp2a1; Pebpa2a; CBF-alpha-1

基因 ID: 12393 | 基因类型: protein coding

关于 Runx2

功能概要

This gene encodes a member of the runt domain-containing family of transcription factors. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Sep 2015]

Runx2 基因产物(6)

mRNA	Protein	Name
NM_001145920.2	NP_001139392.1	runt-related transcription factor 2 isoform 2
NM_001146038.2	NP_001139510.1	runt-related transcription factor 2 isoform 1
NM_001271627.1	NP_001258556.1	runt-related transcription factor 2 isoform 1
NM_001271630.1	NP_001258559.1	runt-related transcription factor 2 isoform 3
NM_001271631.1	NP_001258560.1	runt-related transcription factor 2 isoform 4
NM_009820.5	NP_033950.2	runt-related transcription factor 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	9182762	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	12551949	MGI
enables DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	31545469	MGI
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	12551949	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	9182762	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI IGI: 通过遗传相互作用推断	16751105	MGI
enables bHLH transcription factor binding	IPI IPI: 通过物理相互作用推断	19144722	MGI
enables chromatin DNA binding	IDA IDA: 通过直接分析推断	21930712	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	15537544	MGI
enables cis-regulatory region sequence-specific DNA binding	IMP IMP: 通过突变表型推断	31545469	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	15150273	MGI
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	15030764	MGI
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	12551949	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in BMP signaling pathway	IMP IMP: 通过突变表型推断	20843790	MGI
acts upstream of or within T cell differentiation	IDA IDA: 通过直接分析推断	7862157	MGI
acts upstream of bone mineralization	IDA IDA: 通过直接分析推断	21930712	MGI
acts upstream of bone mineralization	IMP IMP: 通过突变表型推断	21930712	MGI
acts upstream of or within cell maturation	IGI IGI: 通过遗传相互作用推断	15107406	MGI
acts upstream of or within cell maturation	IMP IMP: 通过突变表型推断	15389629	MGI
acts upstream of cell population proliferation	IGI IGI: 通过遗传相互作用推断	16476422	MGI
involved in cell population proliferation	IGI IGI: 通过遗传相互作用推断	22927960	MGI
acts upstream of cell population proliferation	IMP IMP: 通过突变表型推断	15668330	MGI
acts upstream of or within chondrocyte development	IMP IMP: 通过突变表型推断	10213384	MGI
acts upstream of or within chondrocyte differentiation	IGI IGI: 通过遗传相互作用推断	16476422	MGI
acts upstream of chondrocyte differentiation	IMP IMP: 通过突变表型推断	10072783	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: 通过突变表型推断	22916278	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IGI IGI: 通过遗传相互作用推断	15030764	MGI
acts upstream of or within embryonic forelimb morphogenesis	IMP IMP: 通过突变表型推断	22916278	MGI
acts upstream of or within endochondral ossification	IMP IMP: 通过突变表型推断	10072783	MGI
acts upstream of epithelial cell proliferation	IMP IMP: 通过突变表型推断	15668330	MGI
acts upstream of positive effect gene expression	IDA IDA: 通过直接分析推断	21930712	MGI
involved in gene expression	IDA IDA: 通过直接分析推断	31281513	MGI
involved in ligamentous ossification	IGI IGI: 通过遗传相互作用推断	22927960	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	18804520	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: 通过突变表型推断	15668330	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: 通过突变表型推断	15136142	MGI
acts upstream of or within osteoblast development	IGI IGI: 通过遗传相互作用推断	18986983	MGI
involved in osteoblast differentiation	IDA IDA: 通过直接分析推断	21930712	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: 通过遗传相互作用推断	15565649	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: 通过突变表型推断	15389629	MGI
acts upstream of or within osteoblast fate commitment	IGI IGI: 通过遗传相互作用推断	15150273	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12551949	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	31545469	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: 通过遗传相互作用推断	16476422	MGI
acts upstream of or within positive regulation of chondrocyte differentiation	IMP IMP: 通过突变表型推断	10072783	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: 通过突变表型推断	15668330	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: 通过直接分析推断	21324897	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IDA IDA: 通过直接分析推断	15175325	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IGI IGI: 通过遗传相互作用推断	15150273	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: 通过突变表型推断	15668330	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12434156	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9182762	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	15150273	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	31336344	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	20843790	MGI
acts upstream of or within regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	15136142	MGI
acts upstream of or within regulation of gene expression	IDA IDA: 通过直接分析推断	24505141	MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth	IMP IMP: 通过突变表型推断	14688224	MGI
acts upstream of or within regulation of ossification	IMP IMP: 通过突变表型推断	10213384	MGI
acts upstream of or within regulation of osteoblast differentiation	IDA IDA: 通过直接分析推断	21628588	MGI
involved in response to sodium phosphate	IDA IDA: 通过直接分析推断	23523568	MGI
acts upstream of or within skeletal system development	IMP IMP: 通过突变表型推断	14688224	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: 通过突变表型推断	15030764	MGI
acts upstream of smoothened signaling pathway	IMP IMP: 通过突变表型推断	15668330	MGI
acts upstream of or within stem cell differentiation	IDA IDA: 通过直接分析推断	17693062	MGI
acts upstream of stem cell proliferation	IMP IMP: 通过突变表型推断	15668330	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	17352693	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	17182356	MGI
located in nucleus	IDA IDA: 通过直接分析推断	12434156	MGI
part of transcription regulator complex	IDA IDA: 通过直接分析推断	16751105	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

runt-related transcription factor 2

AKV core binding factor	PEA2-alpha A
PEBP2 alpha A	SL3-3 enhancer factor 1 alpha A subunit
acute myeloid leukemia 3 protein	core binding factor alpha 1
osteoblast-specific transcription factor 2	polyomavirus enhancer-binding protein 2 alpha A subun

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-107245	Segetalin B	Activator	99.56%	否
HY-Y0332K	Potassium dihydrogen phosphate, for cell culture	Activator	/	否
HY-W115785	Zinc borate	Activator	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Runx2	NCBI	NCBI:860

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Runx2 - runt related transcription factor 2 Gene

关于 Runx2

功能概要

Runx2 基因产物(6)

直系同源

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Runx2 - runt related transcription factor 2 Gene

关于 Runx2

功能概要

Runx2 基因产物(6)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z