2. Gene
  3. Ctcf - CCCTC-binding factor Gene

Ctcf - CCCTC-binding factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 13018 | 基因类型: protein coding

关于 Ctcf

功能概要

Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in regulation of gene expression and regulation of histone modification. Acts upstream of or within DNA metabolic process and regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 21. Orthologous to human CTCF (CCCTC-binding factor). [provided by Alliance of Genome Resources, Apr 2022]

Ctcf 基因产物(12)

mRNA Protein Name
NM_001358924.2 NP_001345853.1 transcriptional repressor CTCF isoform 2
NM_001403723.1 NP_001390652.1 transcriptional repressor CTCF isoform 1
NM_001403724.1 NP_001390653.1 transcriptional repressor CTCF isoform 1
NM_001403725.1 NP_001390654.1 transcriptional repressor CTCF isoform 1
NM_001403726.1 NP_001390655.1 transcriptional repressor CTCF isoform 2
NM_001403727.1 NP_001390656.1 transcriptional repressor CTCF isoform 2
NM_001403728.1 NP_001390657.1 transcriptional repressor CTCF isoform 2
NM_001403729.1 NP_001390658.1 transcriptional repressor CTCF isoform 3
NM_001403730.1 NP_001390659.1 transcriptional repressor CTCF isoform 3
NM_001403731.1 NP_001390660.1 transcriptional repressor CTCF isoform 4
NM_001403732.1 NP_001390661.1 transcriptional repressor CTCF isoform 4
NM_181322.4 NP_851839.1 transcriptional repressor CTCF isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
12461525 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
22780989 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
28636939 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16949368 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11743158 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA methylation-dependent heterochromatin formation IMP
IMP: 通过突变表型推断
24105743 MGI
acts upstream of or within cardiac muscle cell development IMP
IMP: 通过突变表型推断
28846746 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: 通过突变表型推断
28846746 MGI
involved in chromatin looping IDA
IDA: 通过直接分析推断
28388437 MGI
involved in chromatin looping IMP
IMP: 通过突变表型推断
16951251 MGI
acts upstream of or within chromatin organization IMP
IMP: 通过突变表型推断
28846746 MGI
acts upstream of or within epigenetic regulation of gene expression IDA
IDA: 通过直接分析推断
12461525 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
28846746 MGI
acts upstream of or within genomic imprinting IDA
IDA: 通过直接分析推断
12461525 MGI
acts upstream of or within genomic imprinting IMP
IMP: 通过突变表型推断
14716017 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
28846746 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
28846746 MGI
acts upstream of or within mitochondrion organization IMP
IMP: 通过突变表型推断
28846746 MGI
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
18614575 MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation IMP
IMP: 通过突变表型推断
14716017 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24105743 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
18614575 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15143173 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in male germ cell nucleus IDA
IDA: 通过直接分析推断
12011441 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12075007 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcriptional repressor CTCF

11-zinc finger protein

CTCFL paralog

Ctcf 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Ctcf Q61164 Chd8 Mus musculus Q09XV5
Y2H
16949368
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03287 CTCF Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17635 Ctcf Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24095 Ctcf Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ctcf NCBI NCBI:10664
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