2. Gene
  3. Lck - lymphocyte protein tyrosine kinase Gene

Lck - lymphocyte protein tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Lsk; Lskt; Hck-3; p56Lck; p56

基因 ID: 16818 | 基因类型: protein coding

关于 Lck

功能概要

Enables several functions, including CD4 receptor binding activity; protein antigen binding activity; and protein Phosphatase binding activity. Involved in release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; protein phosphorylation; and regulation of T cell differentiation. Located in cell-cell junction. Colocalizes with plasma membrane. Is expressed in several structures, including 2-cell stage embryo; nervous system; neural ectoderm; sensory organ; and thymus primordium. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human Lck (Lck proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Lck 基因产物(3)

mRNA Protein Name
NM_001162432.1 NP_001155904.1 proto-oncogene tyrosine-protein kinase LCK isoform a
NM_001162433.1 NP_001155905.1 proto-oncogene tyrosine-protein kinase LCK isoform b
NM_010693.3 NP_034823.1 proto-oncogene tyrosine-protein kinase LCK isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CD4 receptor binding IPI
IPI: 通过物理相互作用推断
3262426 MGI
enables protein antigen binding IPI
IPI: 通过物理相互作用推断
21245484 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7486703 MGI
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
24714587 MGI
enables protein tyrosine kinase activity EXP
EXP: 通过实验结果推断
16709819 MGI
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7499277 MGI
enables protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
21487392 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell receptor signaling pathway IDA
IDA: 通过直接分析推断
7499277 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
9177270 MGI
acts upstream of gamma-delta T cell differentiation IMP
IMP: 通过突变表型推断
7807014 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
7499277 MGI
acts upstream of or within positive regulation of gamma-delta T cell differentiation IMP
IMP: 通过突变表型推断
7807014 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: 通过直接分析推断
21357543 MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein IDA
IDA: 通过直接分析推断
11254359 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: 通过直接分析推断
8175795 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
9169414 MGI
acts upstream of or within regulation of T cell receptor signaling pathway IDA
IDA: 通过直接分析推断
14752163 MGI
acts upstream of or within regulation of regulatory T cell differentiation IGI
IGI: 通过遗传相互作用推断
21245484 MGI
involved in release of sequestered calcium ion into cytosol IDA
IDA: 通过直接分析推断
1505025 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
23793062 MGI
colocalizes with plasma membrane IDA
IDA: 通过直接分析推断
3262426 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

proto-oncogene tyrosine-protein kinase LCK

leukocyte C-terminal Src kinase

lymphocyte cell-specific protein-tyrosine kinase

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-15323 PRT062607 Hydrochloride Inhibitor 98.07% Phase 2
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1
Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-132166 Velzatinib Inhibitor 99.40% 否
HY-13561 AZM475271 Inhibitor 99.89% 否
HY-112291 SB 220025 Inhibitor 99.90% 否
HY-15324 PRT062607 acetate Inhibitor 99.83% 否
HY-180888 Lck-IN-5 Inhibitor 98.09% 否
HY-118105 RK-20448 Inhibitor 99.38% 否
HY-114980 BMS-279700 Inhibitor / 否
HY-175193 N-Deshydroxyethyl Dasatinib-C3-NH2 Inhibitor / 否
HY-175281 SJ11646 Degrader / 否
HY-179948 BTK-IN-45 Inhibitor / 否
HY-112448 Lck-IN-6 Inhibitor / 否
HY-175463 LCK degrader-2 Degrader / 否
HY-175437 MRT-7612 Degrader / 否
HY-180928 LCK degrader-3 Degrader / 否
HY-163278 Lck-IN-2 Inhibitor / 否
HY-176194 Antifibrotic agent 1 Inhibitor / 否
HY-120622 BMS-243117 Inhibitor / 否
HY-178014 SIK1-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lck NCBI NCBI:3932
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