2. Gene
  3. Slc12a5 - solute carrier family 12 member 5 Gene

Slc12a5 - solute carrier family 12 member 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Kcc2

基因 ID: 171373 | 基因类型: protein coding

关于 Slc12a5

功能概要

Enables ammonium transmembrane transporter activity and potassium:chloride symporter activity. Involved in several processes, including cation transport; dendritic spine development; and intracellular pH reduction. Located in dendrite membrane and perikaryon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 34 and idiopathic generalized epilepsy 14. Orthologous to human SLC12A5 (solute carrier family 12 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc12a5 基因产物(2)

mRNA Protein Name
NM_001393675.1 NP_001380604.1 solute carrier family 12 member 5 isoform 1
NM_134363.2 NP_599190.1 solute carrier family 12 member 5 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ammonium channel activity IDA
IDA: 通过直接分析推断
15175220 RGD
enables potassium:chloride symporter activity IDA
IDA: 通过直接分析推断
9374636 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15094054 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ammonium transmembrane transport IDA
IDA: 通过直接分析推断
15175220 RGD
involved in chloride transport IDA
IDA: 通过直接分析推断
9374636 RGD
involved in dendritic spine development IDA
IDA: 通过直接分析推断
22345354 RGD
involved in intracellular pH reduction IDA
IDA: 通过直接分析推断
16420452 RGD
involved in postsynaptic neurotransmitter receptor diffusion trapping IDA
IDA: 通过直接分析推断
21878564 RGD
involved in postsynaptic neurotransmitter receptor diffusion trapping IMP
IMP: 通过突变表型推断
21878564 RGD
involved in potassium ion transmembrane transport IDA
IDA: 通过直接分析推断
11551954 RGD
involved in potassium ion transport IDA
IDA: 通过直接分析推断
9374636 RGD
involved in regulation of postsynapse assembly IDA
IDA: 通过直接分析推断
18093524 RGD
involved in regulation of postsynapse assembly IMP
IMP: 通过突变表型推断
18093524 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite membrane IDA
IDA: 通过直接分析推断
12967985 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
21878564 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
21878564 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
12967985 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

solute carrier family 12 member 5

K-Cl cotransporter 2

electroneutral potassium-chloride cotransporter 2

furosemide-sensitive K-Cl cotransporter

neuronal K-Cl cotransporter

neuronal-specific K-Cl cotransporter

solute carrier family 12 (potassium-chloride transporter), member 5

Slc12a5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Slc12a5 Q63633 Mycbp2 Mus musculus Q7TPH6
Anti Bait CoIP
18769030
种属间
Slc12a5 Q63633 Mycbp2 Mus musculus Q7TPH6
Y2H
18769030
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-160082 KCC2 Modulator-2 Modulator / 否
HY-RS13000 SLC12A5 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc12a5 NCBI NCBI:57468
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z