2. Gene
  3. Mre11a - MRE11A homolog A, double strand break repair nuclease Gene

Mre11a - MRE11A homolog A, double strand break repair nuclease Gene

  • 基因
  • 蛋白
  • 相关产品

种属: Mus musculus

同用名: Mre11; Mre11b

基因 ID: 17535 | 基因类型: protein coding

关于 Mre11a

功能概要

Predicted to enable identical protein binding activity; nuclease activity; and protein C-terminus binding activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Acts upstream of or within several processes, including double-strand break repair; homologous chromosome pairing at meiosis; and mitotic DNA damage checkpoint signaling. Located in PML body. Colocalizes with chromosome, telomeric region. Human ortholog(s) of this gene implicated in breast carcinoma; endometrial cancer; stomach carcinoma; and urinary bladder Cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Apr 2022]

Mre11a 基因产物(11)

mRNA Protein Name
NM_001310728.2 NP_001297657.1 double-strand break repair protein MRE11 isoform 2
NM_001411891.1 NP_001398820.1 double-strand break repair protein MRE11 isoform 1
NM_001411892.1 NP_001398821.1 double-strand break repair protein MRE11 isoform 2
NM_001411893.1 NP_001398822.1 double-strand break repair protein MRE11 isoform 3
NM_001411894.1 NP_001398823.1 double-strand break repair protein MRE11 isoform 3
NM_001411895.1 NP_001398824.1 double-strand break repair protein MRE11 isoform 4
NM_001411896.1 NP_001398825.1 double-strand break repair protein MRE11 isoform 5
NM_001411897.1 NP_001398826.1 double-strand break repair protein MRE11 isoform 6
NM_001411898.1 NP_001398827.1 double-strand break repair protein MRE11 isoform 6
NM_001411899.1 NP_001398828.1 double-strand break repair protein MRE11 isoform 7
NM_018736.4 NP_061206.1 double-strand break repair protein MRE11 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclease activity IMP
IMP: 通过突变表型推断
18854157 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17429352 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA strand resection involved in replication fork processing IMP
IMP: 通过突变表型推断
18854157 MGI
acts upstream of or within cell population proliferation IMP
IMP: 通过突变表型推断
9224597 MGI
acts upstream of or within chromosome organization IMP
IMP: 通过突变表型推断
14690604 MGI
involved in chromosome organization IMP
IMP: 通过突变表型推断
18854157 MGI
acts upstream of or within double-strand break repair IMP
IMP: 通过突变表型推断
17291760 MGI
involved in double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
18854157 MGI
acts upstream of or within homologous chromosome pairing at meiosis IMP
IMP: 通过突变表型推断
17291760 MGI
acts upstream of or within mitotic G2 DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
14690604 MGI
acts upstream of or within mitotic intra-S DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
14690604 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Mre11 complex IDA
IDA: 通过直接分析推断
18854157 MGI
located in PML body IDA
IDA: 通过直接分析推断
23444137 MGI
colocalizes with chromosome, telomeric region IDA
IDA: 通过直接分析推断
23444137 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12687013 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

double-strand break repair protein MRE11

MRE11 homolog 1

MRE11 homolog A

double-strand break repair protein MRE11A

meiotic recombination 11 homolog 1

meiotic recombination 11 homolog A

mmMRE11A

Mre11a 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Mre11 Q61216 Nbn Mus musculus Q9R207
Anti Bait CoIP
18854157
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08643 MRE11 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24170 Mre11 Rat Pre-designed siRNA Set A Pre-designed Set / 否
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