Syk - spleen tyrosine kinase Gene

中文名称：脾酪氨酸激酶

种属: Mus musculus

同用名: Sykb

关于 Syk

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动； SH2 域绑定活动；和酶结合活性。参与多个过程，包括细胞表面受体信号通路；参与免疫反应的骨髓细胞激活；和调节囊泡介导的运输。在几个过程的上游或内部起作用，包括白细胞活化的正调节；大分子代谢过程的正向调控；和蛋白质磷酸化。位于早期吞噬体中。 B 细胞受体复合体的一部分。在肝脏中表达。该基因的人类直系同源物与原发性免疫缺陷病有关。与人 SYK（脾相关酪氨酸激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; SH2 domain binding activity; and enzyme binding activity. Involved in several processes, including cell surface receptor signaling pathway; myeloid cell activation involved in immune response; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including positive regulation of leukocyte activation; positive regulation of macromolecule metabolic process; and protein phosphorylation. Located in early phagosome. Part of B cell receptor complex. Is expressed in liver. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human Syk (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]